Literature DB >> 1300308

Role of endothelin-1 in carrageenin-induced inflammation.

A Bertelli1, A Clerico, A Chicca, L Giovannini, A Gorio, M A Romano.   

Abstract

Many vasal factors are produced during an experimental model of inflammation such as rat-paw oedema induced by carrageenin. We investigated whether among the other well-known mediators of inflammation, i.e. serotonin, PAF, eicosanoids and kinins, the peptide endothelin-1 is produced by this kind of inflammatory process caused by carrageenin. Our results indicated that plasma endothelin, and the tissue concentration of endothelin in the oedematous paw, is increased as compared to the control. Consequently, endothelin should also be considered as an important factor in inflammatory processes.

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Year:  1992        PMID： 1300308

Source DB:  PubMed          Journal:  Int J Tissue React        ISSN： 0250-0868


  6 in total

1.  Dual Roles for Endothelin-B Receptors in Modulating Adjuvant-Induced Inflammatory Hyperalgesia in Rats.

Authors:  Alla Khodorova; Shiping Zou; Ke Ren; Ronald Dubner; Gudarz Davar; Gary Strichartz
Journal:  Open Pain J       Date:  2009

2.  Involvement of endogenous endothelins in thermal and mechanical inflammatory hyperalgesia in mice.

Authors:  Ana Baamonde; Ana Lastra; María Villazón; Javier Bordallo; Agustín Hidalgo; Luis Menéndez
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-12-06       Impact factor: 3.000

Review 3.  Endothelin receptors and pain.

Authors:  Alla Khodorova; Jean-Pierre Montmayeur; Gary Strichartz
Journal:  J Pain       Date:  2009-01       Impact factor: 5.820

4.  Early and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1.

Authors:  Alla Khodorova; Judith Richter; Michael R Vasko; Gary Strichartz
Journal:  J Pain       Date:  2009-07       Impact factor: 5.820

5.  Endothelin-1-induced ET(A) receptor-mediated nociception, hyperalgesia and oedema in the mouse hind-paw: modulation by simultaneous ET(B) receptor activation.

Authors:  A P Piovezan; P D'Orléans-Juste; G E Souza; G A Rae
Journal:  Br J Pharmacol       Date:  2000-03       Impact factor: 8.739

6.  Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice.

Authors:  Phuong N Quang; Brian L Schmidt
Journal:  Pain       Date:  2010-03-04       Impact factor: 7.926
  6 in total

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