Literature DB >> 130015

Radiation chemistry of DNA, II. Strand breaks and sugar release by gamma-irradiation of DNA in aqueous solution. The effect of oxygen.

M Dizdaroglu, D Schulte-Frohlinde, C von Sonntag.   

Abstract

From gamma-irradiated oxygenated aqueous solutions of DNA, 2-deoxy-tetrodialdose (1) and 2-deoxy-pentos-4-ulose (2) have been isolated as free sugars. The formation of 1 indicates that in the presence of oxygen the DNA strand is not only broken by mere phosphate ester cleavage but also by C--C-bond rupture in the sugar moiety. Such a process has not been encountered in deoxygenated solutions so far. The mechanism for the formation of 1 is discussed.

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Year:  1975        PMID： 130015     DOI： 10.1515/znc-1975-11-1225

Source DB:  PubMed          Journal:  Z Naturforsch C Biosci        ISSN： 0341-0382


  3 in total

Review 1.  Formation and repair of oxidatively generated damage in cellular DNA.

Authors:  Jean Cadet; Kelvin J A Davies; Marisa Hg Medeiros; Paolo Di Mascio; J Richard Wagner
Journal:  Free Radic Biol Med       Date:  2017-01-02       Impact factor: 7.376

2.  GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin.

Authors:  Bingzi Chen; Xinfeng Zhou; Koli Taghizadeh; Jingyang Chen; JoAnne Stubbe; Peter C Dedon
Journal:  Chem Res Toxicol       Date:  2007-10-19       Impact factor: 3.739

3.  Effect of quadruplex conformation on radiation-induced formation of 8-hydroxyguanine and unaltered base release in polyguanylic acid.

Authors:  D Grygoryev; J D Zimbrick
Journal:  Radiat Res       Date:  2010-01       Impact factor: 2.841
  3 in total

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