Literature DB >> 1300025

Synthesis, antiinflammatory and anticancer activity of cinnamic acids, their derivatives and analogues.

L P Zhang1, Z Z Ji.   

Abstract

Cinnamic acids were selected as lead compounds of antiinflammatory and anticancer agents through the investigation of their biological properties. Their esters and related styryl ketones were also studied. A total of nineteen compounds, fifteen of them not reported previously, were synthesized and found to be of considerable pharmacological interest. In preliminary biological tests, compounds IA, IB, IC, II2C and II5C showed significant inhibiting effect on croton oil induced mouse ear edema, IB, II5A, II5C and IIID exhibited good activity on HL-60 human cancer cells in vitro. It is well worth noticing that compounds IB and II5C exhibited excellent antiinflammatory action as well as anticancer activity.

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Year:  1992        PMID： 1300025

Source DB:  PubMed          Journal:  Yao Xue Xue Bao        ISSN： 0513-4870


  12 in total

1.  Bornyl caffeate induces apoptosis in human breast cancer MCF-7 cells via the ROS- and JNK-mediated pathways.

Authors:  Chuan-bin Yang; Wei-jing Pei; Jia Zhao; Yuan-yuan Cheng; Xiao-hui Zheng; Jian-hui Rong
Journal:  Acta Pharmacol Sin       Date:  2013-12-16       Impact factor: 6.150

2.  Cinnamaldehyde attenuates pressure overload-induced cardiac hypertrophy.

Authors:  Liu Yang; Qing-Qing Wu; Yuan Liu; Zhe-Fu Hu; Zhou-Yan Bian; Qi-Zhu Tang
Journal:  Int J Clin Exp Pathol       Date:  2015-11-01

3.  (E)-Methyl 3-{3-[(4-bromo-phen-oxy)-methyl]phen-yl}acrylate.

Authors:  Xin-Lin Ren; Hui-Rong Zhang; Wei-Dong Wang; Rui-Juan Tao; Hong-Wu He
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

4.  Methyl (Z)-2-[(4-bromo-2-formyl-phen-oxy)meth-yl]-3-(4-methyl-phen-yl)acrylate.

Authors:  S Vijayakumar; S Murugavel; D Kannan; M Bakthadoss
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-02-17

5.  (Z)-Methyl 2-bromo-methyl-3-(2-chloro-phen-yl)acrylate.

Authors:  R Madhanraj; S Vijayakumar; R Selvakumar; M Bakthadoss; S Murugavel
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-30

6.  (Z)-Methyl 2-[(4-bromo-2-formyl-phen-oxy)meth-yl]-3-o-tolyl-acrylate.

Authors:  S Vijayakumar; R Madhanraj; S Murugavel; R Selvakumar; M Bakthadoss
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-20

Review 7.  Antitumor phenylpropanoids found in essential oils.

Authors:  Adriana Andrade Carvalho; Luciana Nalone Andrade; Élida Batista Vieira de Sousa; Damião Pergentino de Sousa
Journal:  Biomed Res Int       Date:  2015-01-15       Impact factor: 3.411

8.  A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.

Authors:  Bing-Yan Zhu; Bo-Yang Shang; Yue Du; Yi Li; Liang Li; Xian-Dong Xu; Yong-Su Zhen
Journal:  Oncotarget       Date:  2017-02-28

9.  Antiproliferative Activity of Cinnamomum cassia Constituents and Effects of Pifithrin-Alpha on Their Apoptotic Signaling Pathways in Hep G2 Cells.

Authors:  Lean-Teik Ng; Shu-Jing Wu
Journal:  Evid Based Complement Alternat Med       Date:  2011-05-02       Impact factor: 2.629

10.  Inhibition of histone deacetylases by trans-cinnamic acid and its antitumor effect against colon cancer xenografts in athymic mice.

Authors:  Bingyan Zhu; Boyang Shang; Yi Li; Yongsu Zhen
Journal:  Mol Med Rep       Date:  2016-03-23       Impact factor: 2.952
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