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Literature DB >> 129972

Pulmonary metastasis formation after intravenous tumour cell injection in defibrinogenated rats.

Abstract

In this study a state of temporary defibrinogenation was induced in rats by Defibrase treatment. It was found that the formation of pulmonary metastases after intravenous tumour cell injection was decreased in defibrinogenated rats. However, defibrinogenation did not influence the effect of trauma and infusion of dextran 1000 on metastasis formation. Both these procedures stimulated the formation of metastases in defibrinogenated rats. These results indicate, that fibrinogen and/or fibrin are of importance for the formation of metastases but that the stimulating effect of trauma and dextran 1000 on metastasis formation is independent of fibrinogen and/or fibrin.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1976 PMID： 129972 DOI： 10.1007/bf00308133

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

24 in total

2. Studies on mechanisms involved in metastasis formation from circulating tumor cells. Factors influencing tumor cell lodgement during normal and post-traumatic conditions.

Authors: G Skolnik; M Alpsten; L Ivarsson
Journal: J Cancer Res Clin Oncol Date: 1980 Impact factor: 4.553

Review 3. Cell detachment and metastasis.

Authors: L Weiss; P M Ward
Journal: Cancer Metastasis Rev Date: 1983 Impact factor: 9.264

4. Inhibition by fibrin coagulation of lung cancer cell destruction by human interleukin-2-activated killer cells.

Authors: S Atagi; S Sone; K Fukuta; T Ogura
Journal: Jpn J Cancer Res Date: 1992-10

5. Lodgement and extravasation of tumour cells in blood-borne metastasis: an electron microscope study.

Authors: M Kinjo
Journal: Br J Cancer Date: 1978-08 Impact factor: 7.640

5 in total

Pulmonary metastasis formation after intravenous tumour cell injection in defibrinogenated rats.

1. INFLUENCE OF FIBRINOGEN DEGRADATION PRODUCTS (FDP) ON PLATELET AGGREGATION, ADHESIVENESS AND VISCOUS METAMORPHOSIS.

2. Intravascular agglutination (sludged blood) vascular stasis and sedimentation rate of blood in trauma.

3. Effect of fibrinolysis on adhesion and aggregation of human platelets.

4. Arvin-induced hypofibrinogenemia and metastasis formation from blood-borne cancer cells.

5. Effect of defibrinogenation and acetylsalicylic acid on the circulatory response to thrombin.

6. Defibrination and metastasis formation: effects of arvin on experimental metastases in mice.

7. In vivo effect of reptilase on fibrinogen metabolism in dogs.

8. Action of heparin and plasminogen inhibitor (EACA) on metastatic tumour spread in an isologous system.

9. Platelet fibrinogen.

10. Heparin, dextran 1000 and metastasis formation after I.V. tumour cell injection in dextran non-sensitive rats.

1. Antimetastatic effect of defibrinogenation with batroxobin depends on the natural killer activity of host in mice.

2. Studies on mechanisms involved in metastasis formation from circulating tumor cells. Factors influencing tumor cell lodgement during normal and post-traumatic conditions.

Review 3. Cell detachment and metastasis.

4. Inhibition by fibrin coagulation of lung cancer cell destruction by human interleukin-2-activated killer cells.

5. Lodgement and extravasation of tumour cells in blood-borne metastasis: an electron microscope study.