Literature DB >> 1297731

Bioavailability and biological activity of L-ascorbic acid 2-O-alpha-glucoside.

I Yamamoto1, N Muto.   

Abstract

AA-2G is a new stable derivative of AsA which is efficiently synthesized by regioselective transglucosylation with alpha-glucosidase and CGTase. AA-2G serves as a vitamin C supplement in experimental animals. AA-2G is easily hydrolyzed in vivo by alpha-glucosidase and also synthesized as a metabolite under some specified conditions. AA-2G stimulates collagen synthesis in cultured fibroblasts and enhances antibody production in cultured splenocytes. AA-2G which has no cytotoxicity is a promising AsA derivative for medical and nutritional uses.

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Year:  1992        PMID: 1297731     DOI: 10.3177/jnsv.38.special_161

Source DB:  PubMed          Journal:  J Nutr Sci Vitaminol (Tokyo)        ISSN: 0301-4800            Impact factor:   2.000


  3 in total

1.  Characterization of Halomonas sp. strain H11 α-glucosidase activated by monovalent cations and its application for efficient synthesis of α-D-glucosylglycerol.

Authors:  Teruyo Ojima; Wataru Saburi; Takeshi Yamamoto; Toshiaki Kudo
Journal:  Appl Environ Microbiol       Date:  2012-01-06       Impact factor: 4.792

2.  Ascorbic Acid 2-Glucoside Pretreatment Protects Cells from Ionizing Radiation, UVC, and Short Wavelength of UVB.

Authors:  Junko Maeda; Allison J Allum; Jacob T Mussallem; Coral E Froning; Alexis H Haskins; Mark A Buckner; Chris D Miller; Takamitsu A Kato
Journal:  Genes (Basel)       Date:  2020-02-25       Impact factor: 4.096

3.  Palmitoyl ascorbic acid 2-glucoside has the potential to protect mammalian cells from high-LET carbon-ion radiation.

Authors:  Alexis H Haskins; Dylan J Buglewicz; Hirokazu Hirakawa; Akira Fujimori; Yasushi Aizawa; Takamitsu A Kato
Journal:  Sci Rep       Date:  2018-09-14       Impact factor: 4.379

  3 in total

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