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Literature DB >> 12975612

The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans.

Patricia M Berninsone¹, Carlos B Hirschberg.

Abstract

The nematode Caenorhabditis elegans is a powerful animal model for exploring the genetic basis of metazoan development. Recent genetic and biochemical studies have revealed that the molecular machinery of glycosaminoglycan (GAG) biosynthesis and modification is highly conserved between C. elegans and mammals. In addition, genetic studies have implicated GAGs in vulval morphogenesis and zygotic cytokinesis. The extensive knowledge of C. elegans biology, including its elucidated cell lineage, together with the completed and well annotated DNA sequence and availability of reverse genetic tools, provide a platform for studying the functions of proteoglycans and their GAG modification.

Entities: Chemical Species

Mesh：

Substances：
Proteoglycans

Year: 2002 PMID： 12975612 DOI： 10.1023/A:1025364820713

Source DB: PubMed Journal: Glycoconj J ISSN： 0282-0080 Impact factor: 2.916

36 in total

1. The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.

Authors: C Senay; T Lind; K Muguruma; Y Tone; H Kitagawa; K Sugahara; K Lidholt; U Lindahl; M Kusche-Gullberg
Journal: EMBO Rep Date: 2000-09 Impact factor: 8.807

Review 2. Order out of chaos: assembly of ligand binding sites in heparan sulfate.

Authors: Jeffrey D Esko; Scott B Selleck
Journal: Annu Rev Biochem Date: 2001-11-09 Impact factor: 23.643

3. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Authors: A Fire; S Xu; M K Montgomery; S A Kostas; S E Driver; C C Mello
Journal: Nature Date: 1998-02-19 Impact factor: 49.962

Review 4. Vulval development in Caenorhabditis elegans.

Authors: K Kornfeld
Journal: Trends Genet Date: 1997-02 Impact factor: 11.639

5. The nematode Caenorhabditis elegans synthesizes unusual O-linked glycans: identification of glucose-substituted mucin-type O-glycans and short chondroitin-like oligosaccharides.

Authors: Y Guérardel; L Balanzino; E Maes; Y Leroy; B Coddeville; R Oriol; G Strecker
Journal: Biochem J Date: 2001-07-01 Impact factor: 3.857

6. Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1.

Authors: Hannes E Bülow; Katherine L Berry; Liat H Topper; Elior Peles; Oliver Hobert
Journal: Proc Natl Acad Sci U S A Date: 2002-04-30 Impact factor: 11.205

7. SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose.

Authors: P Berninsone; H Y Hwang; I Zemtseva; H R Horvitz; C B Hirschberg
Journal: Proc Natl Acad Sci U S A Date: 2001-03-20 Impact factor: 11.205

8. Proteoglycan distribution pattern during aging in the nematode Caenorhabditis elegans: an ultrastructural histochemical study.

Authors: J Schimpf; K Sames; R Zwilling
Journal: Histochem J Date: 1999-05

The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans.

1. The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.

Review 2. Order out of chaos: assembly of ligand binding sites in heparan sulfate.

3. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Review 4. Vulval development in Caenorhabditis elegans.

5. The nematode Caenorhabditis elegans synthesizes unusual O-linked glycans: identification of glucose-substituted mucin-type O-glycans and short chondroitin-like oligosaccharides.

6. Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1.

7. SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose.

8. Proteoglycan distribution pattern during aging in the nematode Caenorhabditis elegans: an ultrastructural histochemical study.

Review 9. Genome sequence of the nematode C. elegans: a platform for investigating biology.

10. The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules.

1. Developmental defects in a Caenorhabditis elegans model for type III galactosemia.

2. Carbohydrate-carbohydrate interaction as a major force initiating cell-cell recognition.

3. XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity.