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Literature DB >> 1297314

Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells.

K Schmidt¹, E R Werner, B Mayer, H Wachter, W R Kukovetz.

Abstract

Inhibition of tetrahydrobiopterin (H4biopterin) biosynthesis in endothelial cells almost completely abolished the agonist-induced formation of endothelium-derived relaxing factor (EDRF) (NO). This inhibitory effect could be antagonized when H4biopterin biosynthesis was restored by activating a salvage pathway. These data indicate that the formation of EDRF strictly depends on the presence of intracellular H4biopterin, which, in addition to Ca2+, may represent a further physiological and/or pathophysiological regulatory of endothelial NO synthases.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1992 PMID： 1297314 PMCID： PMC1130682 DOI： 10.1042/bj2810297

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

29 in total

1. Kinetic characteristics of nitric oxide synthase from rat brain.

Authors: R G Knowles; M Palacios; R M Palmer; S Moncada
Journal: Biochem J Date: 1990-07-01 Impact factor: 3.857

Review 2. Nitric oxide: physiology, pathophysiology, and pharmacology.

Authors: S Moncada; R M Palmer; E A Higgs
Journal: Pharmacol Rev Date: 1991-06 Impact factor: 25.468

3. Establishment of a human cell line highly expressing endothelin in serum-free medium.

Authors: M Kondo; N Ishida; M Kobayashi; Y Mitsui
Journal: J Cardiovasc Pharmacol Date: 1991 Impact factor: 3.105

Review 4. Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.

Authors: C A Nichol; G K Smith; D S Duch
Journal: Annu Rev Biochem Date: 1985 Impact factor: 23.643

5. Analysis of reduced forms of biopterin in biological tissues and fluids.

Authors: T Fukushima; J C Nixon
Journal: Anal Biochem Date: 1980-02 Impact factor: 3.365

6. Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.

Authors: N S Kwon; C F Nathan; D J Stuehr
Journal: J Biol Chem Date: 1989-12-05 Impact factor: 5.157

7. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

Authors: U Förstermann; J S Pollock; H H Schmidt; M Heller; F Murad
Journal: Proc Natl Acad Sci U S A Date: 1991-03-01 Impact factor: 11.205

8. Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate.

Authors: M A Marletta; P S Yoon; R Iyengar; C D Leaf; J S Wishnok
Journal: Biochemistry Date: 1988-11-29 Impact factor: 3.162

9. Serum aluminum levels and erythrocyte dihydropteridine reductase activity in patients on hemodialysis.

Authors: P Altmann; F Al-Salihi; K Butter; P Cutler; J Blair; R Leeming; J Cunningham; F Marsh
Journal: N Engl J Med Date: 1987-07-09 Impact factor: 91.245

10. Biopterin. III. Purification and characterization of enzymes involved in the cerebral synthesis of 7,8-dihydrobiopterin.

Authors: E M Gál; J M Nelson; A D Sherman
Journal: Neurochem Res Date: 1978-02 Impact factor: 3.996

24 in total

1. The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity.

Authors: Satoshi Yamashiro; Yukio Kuniyoshi; Katsuya Arakaki; Kazufumi Miyagi; Kageharu Koja
Journal: Jpn J Thorac Cardiovasc Surg Date: 2002-11

2. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.

Authors: P Rosenkranz-Weiss; W C Sessa; S Milstien; S Kaufman; C A Watson; J S Pober
Journal: J Clin Invest Date: 1994-05 Impact factor: 14.808

Review 3. Nitric oxide synthases in mammals.

Authors: R G Knowles; S Moncada
Journal: Biochem J Date: 1994-03-01 Impact factor: 3.857

4. Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis.

Authors: R J Widmer; M A Freund; A J Flammer; J Sexton; R Lennon; A Romani; N Mulinacci; F F Vinceri; L O Lerman; A Lerman
Journal: Eur J Nutr Date: 2012-08-08 Impact factor: 5.614

5. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

Authors: E Stroes; J Kastelein; F Cosentino; W Erkelens; R Wever; H Koomans; T Lüscher; T Rabelink
Journal: J Clin Invest Date: 1997-01-01 Impact factor: 14.808

6. Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia.

Authors: Y Fukuda; H Teragawa; K Matsuda; T Yamagata; H Matsuura; K Chayama
Journal: Heart Date: 2002-03 Impact factor: 5.994

7. Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.

Authors: Lian Zhang; Fangwen Rao; Kuixing Zhang; Srikrishna Khandrika; Madhusudan Das; Sucheta M Vaingankar; Xuping Bao; Brinda K Rana; Douglas W Smith; Jennifer Wessel; Rany M Salem; Juan L Rodriguez-Flores; Sushil K Mahata; Nicholas J Schork; Michael G Ziegler; Daniel T O'Connor
Journal: J Clin Invest Date: 2007-09 Impact factor: 14.808

Review 8. In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide.

Authors: B Mayer; E R Werner
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1995-05 Impact factor: 3.000

Review 9. Tetrahydrobiopterin, superoxide, and vascular dysfunction.

Authors: Jeannette Vásquez-Vivar
Journal: Free Radic Biol Med Date: 2009-07-21 Impact factor: 7.376

10. Increases in endothelial cyclic AMP levels amplify agonist-induced formation of endothelium-derived relaxing factor (EDRF).

Authors: W F Graier; K Groschner; K Schmidt; W R Kukovetz
Journal: Biochem J Date: 1992-12-01 Impact factor: 3.857