Literature DB >> 12972611

Role of Plk2 (Snk) in mouse development and cell proliferation.

Sheng Ma1, Jean Charron, Raymond L Erikson.   

Abstract

Plk2 (Snk) is a polo-like kinase expressed at G(1) in cultured cells and mainly in the hippocampal neurons in the brains of adult rodents, but its function is poorly understood. We have generated mice deficient in Plk2 by gene targeting. Although Plk2 is not required for postnatal growth, Plk2(-/-) embryos show retarded growth and skeletal development late in gestation. The labyrinthine zone of the placenta is diminished in Plk2(-/-) embryos due to decreased cell proliferation. Cultured Plk2(-/-) embryonic fibroblasts grow more slowly than normal cells and show delayed entry into S phase. These data suggest a role for Plk2 in the cell cycle.

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Year:  2003        PMID： 12972611      PMCID： PMC193943          DOI： 10.1128/MCB.23.19.6936-6943.2003

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  58 in total

1.  The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity.

Authors:  G Kauselmann; M Weiler; P Wulff; S Jessberger; U Konietzko; J Scafidi; U Staubli; J Bereiter-Hahn; K Strebhardt; D Kuhl
Journal:  EMBO J       Date:  1999-10-15       Impact factor: 11.598

2.  Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3.

Authors:  C W Conn; R F Hennigan; W Dai; Y Sanchez; P J Stambrook
Journal:  Cancer Res       Date:  2000-12-15       Impact factor: 12.701

3.  Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta.

Authors:  S Giroux; M Tremblay; D Bernard; J F Cardin-Girard; S Aubry; L Larouche; S Rousseau; J Huot; J Landry; L Jeannotte; J Charron
Journal:  Curr Biol       Date:  1999-04-08       Impact factor: 10.834

4.  Peripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2.

Authors:  C Y Lin; M L Madsen; F R Yarm; Y J Jang; X Liu; R L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

5.  Rescue of cyclin D1 deficiency by knockin cyclin E.

Authors:  Y Geng; W Whoriskey; M Y Park; R T Bronson; R H Medema; T Li; R A Weinberg; P Sicinski
Journal:  Cell       Date:  1999-06-11       Impact factor: 41.582

6.  Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.

Authors:  Y Sanchez; J Bachant; H Wang; F Hu; D Liu; M Tetzlaff; S J Elledge
Journal:  Science       Date:  1999-11-05       Impact factor: 47.728

7.  Mitotic effects of a constitutively active mutant of the Xenopus polo-like kinase Plx1.

Authors:  Y W Qian; E Erikson; J L Maller
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

8.  Polo-like kinase-1 is a target of the DNA damage checkpoint.

Authors:  V A Smits; R Klompmaker; L Arnaud; G Rijksen; E A Nigg; R H Medema
Journal:  Nat Cell Biol       Date:  2000-09       Impact factor: 28.824

9.  Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.

Authors:  U Holtrich; G Wolf; J Yuan; J Bereiter-Hahn; T Karn; M Weiler; G Kauselmann; M Rehli; R Andreesen; M Kaufmann; D Kuhl; K Strebhardt
Journal:  Oncogene       Date:  2000-10-05       Impact factor: 9.867

10.  A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis.

Authors:  S Song; K S Lee
Journal:  J Cell Biol       Date:  2001-02-05       Impact factor: 10.539
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  59 in total

Review 1.  Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy.

Authors:  Kyung S Lee; Terrence R Burke; Jung-Eun Park; Jeong K Bang; Eunhye Lee
Journal:  Trends Pharmacol Sci       Date:  2015-10-17       Impact factor: 14.819

2.  Calcipotriol affects keratinocyte proliferation by decreasing expression of early growth response-1 and polo-like kinase-2.

Authors:  Jernej Kristl; Petra Slanc; Metka Krasna; Ales Berlec; Matjaz Jeras; Borut Strukelj
Journal:  Pharm Res       Date:  2007-08-02       Impact factor: 4.200

3.  Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus.

Authors:  Sean M O'Donnell; Geoffrey H Holm; Janene M Pierce; Bing Tian; Melissa J Watson; Ravi S Chari; Dean W Ballard; Allan R Brasier; Terence S Dermody
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

Review 4.  Polo-like kinases: structural variations lead to multiple functions.

Authors:  Sihem Zitouni; Catarina Nabais; Swadhin Chandra Jana; Adán Guerrero; Mónica Bettencourt-Dias
Journal:  Nat Rev Mol Cell Biol       Date:  2014-07       Impact factor: 94.444

5.  Structural analysis of the polo-box domain of human Polo-like kinase 2.

Authors:  Ju Hee Kim; Bonsu Ku; Kyung S Lee; Seung Jun Kim
Journal:  Proteins       Date:  2015-04-28

6.  BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival.

Authors:  Kristina Lotz; George Pyrowolakis; Stefan Jentsch
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

Review 7.  The role of Plk3 in oncogenesis.

Authors:  C Helmke; S Becker; K Strebhardt
Journal:  Oncogene       Date:  2015-04-27       Impact factor: 9.867

8.  The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.

Authors:  Elizabeth M Matthew; Lori S Hart; Aristotelis Astrinidis; Arunasalam Navaraj; Nathan G Dolloff; David T Dicker; Elizabeth P Henske; Wafik S El-Deiry
Journal:  Cell Cycle       Date:  2009-12-15       Impact factor: 4.534

9.  Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.

Authors:  Annekatrin Krause; Ingrid Hoffmann
Journal:  PLoS One       Date:  2010-03-24       Impact factor: 3.240

10.  Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.

Authors:  Kelly J Inglis; David Chereau; Elizabeth F Brigham; San-San Chiou; Susanne Schöbel; Normand L Frigon; Mei Yu; Russell J Caccavello; Seth Nelson; Ruth Motter; Sarah Wright; David Chian; Pamela Santiago; Ferdie Soriano; Carla Ramos; Kyle Powell; Jason M Goldstein; Michael Babcock; Ted Yednock; Frederique Bard; Guriqbal S Basi; Hing Sham; Tamie J Chilcote; Lisa McConlogue; Irene Griswold-Prenner; John P Anderson
Journal:  J Biol Chem       Date:  2008-11-12       Impact factor: 5.157
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