Literature DB >> 12972333

Solubilization of Fluasterone in cosolvent/cyclodextrin combinations.

Yan He1, Ping Li, Samuel H Yalkowsky.   

Abstract

The combined effect of cosolvent (methanol (MeOH), ethanol (EtOH), or n-propanol (n-PrOH)) and complexant hydroxypropyl-beta-cyclodextrin (HP beta CD) on the solubility of Fluasterone is evaluated and explained with a simple equation. The calculated constants in the equation not only quantitatively describe the dependence of drug solubility on cosolvent and ligand concentrations, but also explain the minima that are observed in the Fluasterone solubility versus cosolvent concentration curves at fixed HP beta CD concentrations.

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Year:  2003        PMID： 12972333     DOI： 10.1016/s0378-5173(03)00389-2

Source DB:  PubMed          Journal:  Int J Pharm        ISSN： 0378-5173            Impact factor:   5.875


  6 in total

1.  Immediate Release Formulation of Inhaled Beclomethasone Dipropionate-Hydroxypropyl-Beta-Cyclodextrin Composite Particles Produced Using Supercritical Assisted Atomization.

Authors:  Hsien-Tsung Wu; Yao-Hsiang Chuang; Han-Cyuan Lin; Tzu-Chieh Hu; Yi-Jia Tu; Liang-Jung Chien
Journal:  Polymers (Basel)       Date:  2022-05-23       Impact factor: 4.967

2.  The influence of cosolvent on the complexation of HP-beta-cyclodextrins with oleanolic acid and ursolic acid.

Authors:  Rui Li; Peng Quan; Dong-Fei Liu; Fang-Di Wei; Qing Zhang; Qun-Wei Xu
Journal:  AAPS PharmSciTech       Date:  2009-10-16       Impact factor: 3.246

3.  Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug.

Authors:  Suporn Charumanee; Siriporn Okonogi; Jakkapan Sirithunyalug; Peter Wolschann; Helmut Viernstein
Journal:  Sci Pharm       Date:  2016-10-18

4.  Application of the Solute-Solvent Intermolecular Interactions as Indicator of Caffeine Solubility in Aqueous Binary Aprotic and Proton Acceptor Solvents: Measurements and Quantum Chemistry Computations.

Authors:  Tomasz Jeliński; Maciej Kubsik; Piotr Cysewski
Journal:  Materials (Basel)       Date:  2022-03-27       Impact factor: 3.623

5.  Co-solvation effect on the binding mode of the α-mangostin/β-cyclodextrin inclusion complex.

Authors:  Thanyada Rungrotmongkol; Uracha Ruktanonchai; Chompoonut Rungnim; Sarunya Phunpee; Manaschai Kunaseth; Supawadee Namuangruk; Kanin Rungsardthong
Journal:  Beilstein J Org Chem       Date:  2015-11-25       Impact factor: 2.883

Review 6.  Solubility of Cyclodextrins and Drug/Cyclodextrin Complexes.

Authors:  Phennapha Saokham; Chutimon Muankaew; Phatsawee Jansook; Thorsteinn Loftsson
Journal:  Molecules       Date:  2018-05-11       Impact factor: 4.411
  6 in total

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