Literature DB >> 12971835

Epilepsy in the elderly.

Suzette M LaRoche1, Sandra L Helmers.   

Abstract

BACKGROUND: Epilepsy is one of the most common neurologic diseases that affect the elderly population. Underlying etiologies as well as diagnostic and treatment issues vary from that of younger adults and deserve special consideration. REVIEW
SUMMARY: The substantially increased risk of seizures and epilepsy in the elderly is associated with medical conditions that affect this group such as stroke, dementia, and metabolic disturbances. In addition, there is an increased incidence and associated mortality of status epilepticus among seniors. Distinguishing epilepsy from paroxysmal nonepileptic events can be a particular challenge. As in the general adult population, EEG and MRI are the cornerstones of diagnostic assessment; however, the clinician must be aware of nonspecific changes associated with aging that do not necessarily indicate an underlying predisposition for epilepsy. Finally, there are unique challenges to the treatment of epilepsy in this population, but fortunately there are multiple treatment options available, including nonpharmacological therapies.
CONCLUSIONS: Knowledge of the unique challenges in identifying and treating the elderly patient with epilepsy is important for effective management as well as maximizing quality of life. However, further studies in this area are still needed to establish optimal treatment strategies.

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Year:  2003        PMID: 12971835     DOI: 10.1097/01.nrl.0000087719.64343.be

Source DB:  PubMed          Journal:  Neurologist        ISSN: 1074-7931            Impact factor:   1.398


  10 in total

1.  Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of low-grade gliomas: a clinicopathological study.

Authors:  Gan You; Zhi-Yi Sha; Wei Yan; Wei Zhang; Yong-Zhi Wang; Shao-Wu Li; Lin Sang; Zi Wang; Gui-Lin Li; Shou-Wei Li; Yi-Jun Song; Chun-Sheng Kang; Tao Jiang
Journal:  Neuro Oncol       Date:  2011-12-19       Impact factor: 12.300

2.  Vulnerability of hippocampal GABA-ergic interneurons to kainate-induced excitotoxic injury during old age.

Authors:  Ashok K Shetty; Bharathi Hattiangady; Muddanna S Rao
Journal:  J Cell Mol Med       Date:  2009-08       Impact factor: 5.310

3.  Acute Seizures in Old Age Leads to a Greater Loss of CA1 Pyramidal Neurons, an Increased Propensity for Developing Chronic TLE and a Severe Cognitive Dysfunction.

Authors:  Bharathi Hattiangady; Ramkumar Kuruba; Ashok K Shetty
Journal:  Aging Dis       Date:  2011-02-01       Impact factor: 6.745

Review 4.  Review of topiramate for the treatment of epilepsy in elderly patients.

Authors:  B R Sommer; H H Fenn
Journal:  Clin Interv Aging       Date:  2010-04-26       Impact factor: 4.458

5.  Status epilepticus during old age is not associated with enhanced hippocampal neurogenesis.

Authors:  Muddanna S Rao; Bharathi Hattiangady; Ashok K Shetty
Journal:  Hippocampus       Date:  2008       Impact factor: 3.899

6.  Plasticity of hippocampal stem/progenitor cells to enhance neurogenesis in response to kainate-induced injury is lost by middle age.

Authors:  Bharathi Hattiangady; Muddanna S Rao; Ashok K Shetty
Journal:  Aging Cell       Date:  2008-01-28       Impact factor: 9.304

7.  Differential susceptibility of interneurons expressing neuropeptide Y or parvalbumin in the aged hippocampus to acute seizure activity.

Authors:  Ramkumar Kuruba; Bharathi Hattiangady; Vipan K Parihar; Bing Shuai; Ashok K Shetty
Journal:  PLoS One       Date:  2011-09-06       Impact factor: 3.240

8.  Hypokalemia-induced abnormal movements: case report.

Authors:  Alireza Baratloo; Alaleh Rouhipour; Mohammadmahdi Forouzanfar; Farhad Rahmati; Behrooz Hashemi
Journal:  Trauma Mon       Date:  2013-10-13

Review 9.  Acute Symptomatic Seizures Caused by Electrolyte Disturbances.

Authors:  Raffaele Nardone; Francesco Brigo; Eugen Trinka
Journal:  J Clin Neurol       Date:  2016-01       Impact factor: 3.077

10.  New-Onset Geriatric Epilepsy in China: A Single-Center Study.

Authors:  Jian-Hua Chen; Xiang-Qin Zhou; Qiang Lu; Li-Ri Jin; Yan Huang
Journal:  Chin Med J (Engl)       Date:  2018-12-20       Impact factor: 2.628

  10 in total

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