Literature DB >> 1297146

Beta A4 amyloid protein and its precursor in Alzheimer's disease.

A I Bush1, K Beyreuther, C L Masters.   

Abstract

The beta A4 amyloid protein is now understood to play a pivotal role in the development of Alzheimer's disease. This protein is generated by the abnormal processing of the amyloid protein precursor, a large membrane glycoprotein. Insights into the mechanisms of this abnormal processing will give information relevant to the design of new therapeutic strategies for Alzheimer's disease.

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Year:  1992        PMID： 1297146     DOI： 10.1016/0163-7258(92)90039-3

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  6 in total

Review 1.  Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples.

Authors:  A Pascale; S Govoni; F Battaini
Journal:  Mol Neurobiol       Date:  1998-02       Impact factor: 5.590

2.  Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts.

Authors:  A Favit; M Grimaldi; T J Nelson; D L Alkon
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-12       Impact factor: 11.205

3.  Identification of structural variations in the carboxyl terminus of Alzheimer's disease-associated beta A4[1-42] amyloid using a monoclonal antibody.

Authors:  U L Jayasena; S K Gribble; A McKenzie; K Beyreuther; C L Masters; J R Underwood
Journal:  Clin Exp Immunol       Date:  2001-05       Impact factor: 4.330

4.  Alzheimer and beta-amyloid-treated fibroblasts demonstrate a decrease in a memory-associated GTP-binding protein, Cp20.

Authors:  C S Kim; Y F Han; R Etcheberrigaray; T J Nelson; J L Olds; T Yoshioka; D L Alkon
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

5.  Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy.

Authors:  M L Schmidt; K A Robinson; V M Lee; J Q Trojanowski
Journal:  Am J Pathol       Date:  1995-08       Impact factor: 4.307

6.  Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia.

Authors:  Abu Saleh Md Moin; Hassan Kahal; Ahmed Al-Qaissi; Nitya Kumar; Thozhukat Sathyapalan; Stephen L Atkin; Alexandra E Butler
Journal:  BMJ Open Diabetes Res Care       Date:  2021-04
  6 in total

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