Literature DB >> 12969964

Adult human hematopoietic cells provide functional hemangioblast activity.

Christopher R Cogle1, David A Wainman, Marda L Jorgensen, Steven M Guthrie, Robert N Mames, Edward W Scott.   

Abstract

The murine adult hematopoietic stem cell is able to function as a hemangioblast, contributing both to blood reconstitution and to blood vessel repair in response to ischemic injury. We developed a novel mouse xenotransplantation model of retinal neovascularization to test human hematopoietic cell plasticity. Immunocompromised nonobese diabetic (NOD)/scid mice underwent myeloablative conditioning and transplantation with human CD34+ umbilical cord blood. After multilineage reconstitution was established, retinal ischemia was induced to promote neovascularization. Our results demonstrate human retinal neovascularization, thus revealing the functional hemangioblast activity of human hematopoietic cells.

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Year:  2003        PMID： 12969964     DOI： 10.1182/blood-2003-06-2101

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  20 in total

1.  Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury.

Authors:  Jeffrey R Harris; Gary A J Brown; Marda Jorgensen; Shalesh Kaushal; E Ann Ellis; Maria B Grant; Edward W Scott
Journal:  Invest Ophthalmol Vis Sci       Date:  2006-05       Impact factor: 4.799

Review 2.  Stem cell plasticity, beyond alchemy.

Authors:  Michael S Rutenberg; Takashi Hamazaki; Amar M Singh; Naohiro Terada
Journal:  Int J Hematol       Date:  2004-01       Impact factor: 2.490

Review 3.  Hemangioblasts representing a functional endothelio-hematopoietic entity in ontogeny, postnatal life, and CML neovasculogenesis.

Authors:  Gregor Prindull
Journal:  Stem Cell Rev       Date:  2005       Impact factor: 5.739

Review 4.  Adult stem cell plasticity: introduction to the first issue of stem cell reviews.

Authors:  Stewart Sell
Journal:  Stem Cell Rev       Date:  2005       Impact factor: 5.739

5.  Bone marrow stem and progenitor cell contribution to neovasculogenesis is dependent on model system with SDF-1 as a permissive trigger.

Authors:  Gerard J Madlambayan; Jason M Butler; Koji Hosaka; Marda Jorgensen; Dongtao Fu; Steven M Guthrie; Anitha K Shenoy; Adam Brank; Kathryn J Russell; Jaclyn Otero; Dietmar W Siemann; Edward W Scott; Christopher R Cogle
Journal:  Blood       Date:  2009-08-28       Impact factor: 22.113

Review 6.  Molecular and developmental biology of the hemangioblast.

Authors:  Jing-Wei Xiong
Journal:  Dev Dyn       Date:  2008-05       Impact factor: 3.780

7.  Development of a network to test strategies in cardiovascular cell delivery: the NHLBI-sponsored Cardiovascular Cell Therapy Research Network (CCTRN).

Authors:  Robert D Simari; Lemuel A Moyé; Sonia I Skarlatos; Stephen G Ellis; David X M Zhao; James T Willerson; Timothy D Henry; Carl J Pepine
Journal:  J Cardiovasc Transl Res       Date:  2010-02       Impact factor: 4.132

8.  SDF-1 is both necessary and sufficient to promote proliferative retinopathy.

Authors:  Jason M Butler; Steven M Guthrie; Mehmet Koc; Aqeela Afzal; Sergio Caballero; H Logan Brooks; Robert N Mames; Mark S Segal; Maria B Grant; Edward W Scott
Journal:  J Clin Invest       Date:  2005-01       Impact factor: 14.808

9.  Generation of functional hemangioblasts from human embryonic stem cells.

Authors:  Shi-Jiang Lu; Qiang Feng; Sergio Caballero; Yu Chen; Malcolm A S Moore; Maria B Grant; Robert Lanza
Journal:  Nat Methods       Date:  2007-05-07       Impact factor: 28.547

10.  Effect of Calcium-Infiltrated Hydroxyapatite Scaffolds on the Hematopoietic Fate of Human Umbilical Vein Endothelial Cells.

Authors:  Qinghao Zhang; Jörg C Gerlach; Eva Schmelzer; Ian Nettleship
Journal:  J Vasc Res       Date:  2017-11-23       Impact factor: 1.934
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