Literature DB >> 12969773

The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock.

Marika Collin1, Christoph Thiemermann.   

Abstract

We demonstrate here for the first time that the endogenous cyclopentenone prostaglandin 15-deoxy-Delta12,14-prostaglandin J2 (15d-prostaglandin J2) reduces the liver injury (rise in serum transaminases) caused by severe endotoxaemia (6 mg/kg Escherichia coli endotoxin i.v. for 6 h) in the anaesthetised rat. The protection of the liver afforded by this potent agonist of PPAR-gamma was not secondary to a haemodynamic effect. Thus, 15d-prostaglandin J2 and other PPAR-gamma agonists may be useful in the therapy of septic shock.

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Year:  2003        PMID： 12969773     DOI： 10.1016/s0014-2999(03)02179-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

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Journal:  Mol Neurobiol       Date:  2022-04-18       Impact factor: 5.590

2.  Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia.

Authors:  Balázs Hauser; Jochen Kick; Zsolt Iványi; Pierre Asfar; Ulrich Ehrmann; Claus-Martin Muth; Maura Albicini; Ulrich Wachter; Josef Vogt; Michael Bauer; Uwe Bernd Brückner; Peter Radermacher; Hendrik Bracht
Journal:  Intensive Care Med       Date:  2006-03-14       Impact factor: 17.440

3.  Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure.

Authors:  C Thiemermann
Journal:  Br J Pharmacol       Date:  2003-12-08       Impact factor: 8.739

4.  Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinson's Disease.

Authors:  L Hunter Randy; Bing Guoying
Journal:  Curr Neuropharmacol       Date:  2007-03       Impact factor: 7.363

5.  The possible role of peroxisome proliferator-activated receptor gamma in heart failure.

Authors:  Natsuhiko Ehara; Koh Ono; Tatsuya Morimoto; Teruhisa Kawamura; Mitsuru Abe; Koji Hasegawa
Journal:  Exp Clin Cardiol       Date:  2004

6.  Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure.

Authors:  Christoph Thiemermann
Journal:  Br J Pharmacol       Date:  2004-07       Impact factor: 8.739

7.  Management of cardiac fibrosis in diabetic rats; the role of peroxisome proliferator activated receptor gamma (PPAR-gamma) and calcium channel blockers (CCBs).

Authors:  Hoda E Mohamad; Mervat E Askar; Mohamed M Hafez
Journal:  Diabetol Metab Syndr       Date:  2011-03-30       Impact factor: 3.320

8.  Microwave assisted synthesis of novel functionalized hydantoin derivatives and their conversion to 5-(Z) arylidene-4H-imidazoles.

Authors:  Sukanta Kamila; Haribabu Ankati; Edward R Biehl
Journal:  Molecules       Date:  2011-06-29       Impact factor: 4.411
  8 in total

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