BACKGROUND: Oral squamous cell carcinoma (SCC) develops from pre-malignant lesions, but the role of cell adhesion molecules such as E-cadherin (E-CD) and P-cadherin (P-CD) in the pre-malignant stage has not been elucidated. METHODS: The expression of E-CD and P-CD was examined immunohistochemically and biochemically in a 4-nitroquinoline 1-oxide (4NQO)-induced rat model of carcinogenesis. RESULTS: The expression of E-CD in the pre-malignant stage was the same as that in the normal epithelium. The expression of P-CD was even throughout the prickle cell layer in the dysplasia stage. E-CD and P-CD were expressed in essentially the same locations in SCC and in the pre-malignant stage. P-CD expression was very strong in the pre-malignant stage, compared to that in normal epithelium. CONCLUSIONS: Aberrant P-CD expression in E-CD-positive cells may play a crucial role in the progression of the pre-malignant stage of 4NQO-induced carcinogenesis, and may activate mechanisms responsible for cell proliferation.
BACKGROUND: Oral squamous cell carcinoma (SCC) develops from pre-malignant lesions, but the role of cell adhesion molecules such as E-cadherin (E-CD) and P-cadherin (P-CD) in the pre-malignant stage has not been elucidated. METHODS: The expression of E-CD and P-CD was examined immunohistochemically and biochemically in a 4-nitroquinoline 1-oxide (4NQO)-induced rat model of carcinogenesis. RESULTS: The expression of E-CD in the pre-malignant stage was the same as that in the normal epithelium. The expression of P-CD was even throughout the prickle cell layer in the dysplasia stage. E-CD and P-CD were expressed in essentially the same locations in SCC and in the pre-malignant stage. P-CD expression was very strong in the pre-malignant stage, compared to that in normal epithelium. CONCLUSIONS: Aberrant P-CD expression in E-CD-positive cells may play a crucial role in the progression of the pre-malignant stage of 4NQO-induced carcinogenesis, and may activate mechanisms responsible for cell proliferation.
Authors: Xiaoqin Liu; Qian Li; Yang Wang; Madeleine Crawford; Parnit K Bhupal; Xiuqing Gao; Huan Xie; Dong Liang; Yi-Shing L Cheng; Xiaohua Liu; Robert Y L Tsai Journal: Small Date: 2022-05-19 Impact factor: 15.153
Authors: Lorenzo Lo Muzio; Giuseppina Campisi; Antonio Farina; Corrado Rubini; Giuseppe Pannone; Rosario Serpico; Gregorio Laino; Alfredo De Lillo; Francesco Carinci Journal: BMC Cancer Date: 2005-06-21 Impact factor: 4.430