Literature DB >> 12968906

Synthesis of bioactive sesterterpenolides from ent-halimic acid. 15-epi-ent-Cladocoran A and B.

I S Marcos1, A B Pedrero, M J Sexmero, D Diez, P Basabe, N García, R F Moro, H B Broughton, F Mollinedo, J G Urones.   

Abstract

The bioactive sesterterpenoid gamma-hydroxybutenolides 15,18-bisepi-ent-Cladocoran A and B, 1 and 2, and 15-epi-ent-Cladocoran A and B, 57 and 55, were synthesized from ent-halimic acid. The synthesized sesterterpenolids 2, 55, 57, and 59 inhibited cellular proliferation (IC(50) congruent with 2 micro M) of a number of human leukaemic and solid tumor cell lines.

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Year:  2003        PMID： 12968906     DOI： 10.1021/jo034663l

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  Synthetic studies towards the ent-labdane diterpenoids: rearrangement of ent-halimanes.

Authors:  Isidro S Marcos; María J Sexmero; Felix A Hernández; Marta Corrales; Pilar Basabe; David Díez; Julio G Urones
Journal:  Molecules       Date:  2006-10-24       Impact factor: 4.411

2.  Synthesis of Bioconjugate Sesterterpenoids with Phospholipids and Polyunsaturated Fatty Acids.

Authors:  Ana Gil-Mesón; Alejandro M Roncero; Ignacio E Tobal; Pilar Basabe; David Díez; Faustino Mollinedo; Isidro S Marcos
Journal:  Molecules       Date:  2015-12-30       Impact factor: 4.411

Review 3.  The Methylene-Cycloalkylacetate (MCA) Scaffold in Terpenyl Compounds with Potential Pharmacological Activities.

Authors:  Ignacio E Tobal; Alejandro M Roncero; Rosalina F Moro; David Díez; Isidro S Marcos
Journal:  Molecules       Date:  2019-06-05       Impact factor: 4.411

4.  Synthesis of an ent-halimanolide from ent-halimic acid.

Authors:  Isidro S Marcos; Almudena Conde; Rosalina F Moro; Pilar Basabe; David Díez; Faustino Mollinedo; Julio G Urones
Journal:  Molecules       Date:  2008-05-09       Impact factor: 4.411
  4 in total

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