Literature DB >> 12968835

QTc prolongation due to propranolol overdose.

Vida Farhangi1, Randy A Sansone.   

Abstract

Prolongation of the QTc interval (a QT interval that has been corrected for heart rate) increases the risk of cardiac arrhythmias, and is an important topic with regard to psychotropic medication. Several typical (e.g., pimozide, thioridazine, haloperidol) and atypical (e.g., sertindole, ziprasidone) antipsychotics may cause QTc prolongation as well as some antidepressants in overdose (e.g., citalopram). We wish to present a case of QTc prolongation that was due to an overdose of propranolol (used in psychiatry for the treatment of akathisia, lithium-induced tremor, and performance anxiety; used in medicine for hypertension and congestive heart failure).

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Year:  2003        PMID: 12968835     DOI: 10.2190/KLBE-UWHT-TARV-8E0M

Source DB:  PubMed          Journal:  Int J Psychiatry Med        ISSN: 0091-2174            Impact factor:   1.210


  2 in total

1.  Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy.

Authors:  Kazunobu Kawakami; Toshihisa Nagatomo; Haruhiko Abe; Kan Kikuchi; Hiroko Takemasa; Blake D Anson; Brian P Delisle; Craig T January; Yasuhide Nakashima
Journal:  Br J Pharmacol       Date:  2006-03       Impact factor: 8.739

2.  Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model.

Authors:  X Yao; D L Anderson; S A Ross; D G Lang; B Z Desai; D C Cooper; P Wheelan; M S McIntyre; M L Bergquist; K I MacKenzie; J D Becherer; M A Hashim
Journal:  Br J Pharmacol       Date:  2008-06-30       Impact factor: 8.739

  2 in total

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