Literature DB >> 12968816

Economic consequences of underuse of generic drugs: evidence from Medicaid and implications for prescription drug benefit plans.

Michael A Fischer1, Jerry Avorn.   

Abstract

OBJECTIVE: To calculate the financial impact of underuse of generic medications in state Medicaid programs. DATA SOURCES/STUDY
SETTING: State-by-state data on Medicaid drug spending for 48 states and the District of Columbia in calendar year 2000. STUDY
DESIGN: We compared the total amount paid by each state Medicaid program for brand name prescriptions with the amount that would have been paid for generic versions of the same agent, to estimate the level of unrealized savings from use of substitutable generic drugs. We also examined whether variation in prices between states represented a potential source of unrealized savings. PRINCIPAL
FINDINGS: Analysis of state-by-state Medicaid prescription drug spending in 2000 identified potential savings of $229 million that could have been realized from greater use of generic drugs. If the best available prices from each state had been used nationally, savings would have increased to $450 million. The majority of the unrealized savings were concentrated in a small group of medications, including clozapine, alprazolam, and levothyroxine.
CONCLUSIONS: Federal regulations on prescription drug reimbursement limit the excess spending on brand name drugs in the Medicaid program to a small percentage of total spending, although the absolute dollar amount is large. Further savings could be realized if lowest available prices were used nationwide. Concentrating on specific agents may be a productive way to address the unrealized savings.

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Year:  2003        PMID: 12968816      PMCID: PMC1360932          DOI: 10.1111/1475-6773.00162

Source DB:  PubMed          Journal:  Health Serv Res        ISSN: 0017-9124            Impact factor:   3.402


  23 in total

1.  Users' Guides to the Medical Literature: XIX. Applying clinical trial results B. Guidelines for determining whether a drug is exerting (more than) a class effect.

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2.  How companies stall generics and keep themselves healthy.

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8.  Bioequivalence of a generic slow-release theophylline tablet in children.

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Journal:  J Pediatr       Date:  1994-12       Impact factor: 4.406

9.  Digoxin-prescribing. Mostly good news.

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Journal:  JAMA       Date:  1979-08-03       Impact factor: 56.272

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Authors:  L Hendeles; A L Breton; R Beaty; E Harman
Journal:  Pharmacotherapy       Date:  1995 Jan-Feb       Impact factor: 4.705

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  19 in total

1.  Tribute to John M. Eisenberg.

Authors:  Ann Barry Flood; Harold S Luft
Journal:  Health Serv Res       Date:  2003-08       Impact factor: 3.402

2.  Use of fibrates in the United States and Canada.

Authors:  Cynthia A Jackevicius; Jack V Tu; Joseph S Ross; Dennis T Ko; Daniel Carreon; Harlan M Krumholz
Journal:  JAMA       Date:  2011-03-23       Impact factor: 56.272

3.  Sources of regional variation in Medicare Part D drug spending.

Authors:  Julie M Donohue; Nancy E Morden; Walid F Gellad; Julie P Bynum; Weiping Zhou; Joseph T Hanlon; Jonathan Skinner
Journal:  N Engl J Med       Date:  2012-02-09       Impact factor: 91.245

4.  The National e-Prescribing Patient Safety Initiative: removing one hurdle, confronting others.

Authors:  Michael A Fischer
Journal:  Drug Saf       Date:  2007       Impact factor: 5.606

5.  Clinical outcomes after conversion from brand-name tacrolimus (prograf) to a generic formulation in renal transplant recipients: a retrospective cohort study.

Authors:  Kwaku Marfo; Samuel Aitken; Enver Akalin
Journal:  P T       Date:  2013-08

6.  Medicaid Expenditures and Estimated Rebates for Epinephrine Autoinjectors, 2012 to 2016.

Authors:  Jing Luo; Aaron S Kesselheim; Jerry Avorn
Journal:  JAMA Intern Med       Date:  2017-05-01       Impact factor: 21.873

7.  A comparison of drug formularies and the potential for cost-savings.

Authors:  Andrea L Kjos; Jon C Schommer; Yingli Yuan
Journal:  Am Health Drug Benefits       Date:  2010-09

8.  Perceptions and behaviors of patients and pharmacists towards generic drug substitution in Lebanon.

Authors:  Shadi Saleh; Clara Abou Samra; Stewart Jleilaty; Joanne Constantin; Nour El Arnaout; Hani Dimassi; Dania Al-Bittar
Journal:  Int J Clin Pharm       Date:  2017-08-19

9.  Association of income and prescription drug coverage with generic medication use among older adults with hypertension.

Authors:  Alex D Federman; Ethan A Halm; Carolyn Zhu; Tsivia Hochman; Albert L Siu
Journal:  Am J Manag Care       Date:  2006-10       Impact factor: 2.229

10.  Beliefs about generic drugs among elderly adults in hospital-based primary care practices.

Authors:  Alice Iosifescu; Ethan A Halm; Thomas McGinn; Albert L Siu; Alex D Federman
Journal:  Patient Educ Couns       Date:  2008-11
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