| Literature DB >> 12968212 |
T Ikeda1, Y Nishijima, H Shibata, Y Kiso, K Ohnuki, T Fushiki, T Moritani.
Abstract
To investigate the mechanism of antioxidative effects of sesamin in vivo, 32 male ddY mice were administered with 10 mg/kg or 100 mg/kg of sesamin (S10, S100), 100 mg/kg of vitamin E (VE100) or control sample (C). They were subjected to 30 min of swimming exercise 2 h after the sample administration by using a new forced-swimming apparatus, i. e. an adjustable-current swimming pool. Exercise resulted in a significant increase in plasma lipid peroxides (LPO) in C and VE100 (p < 0.01), but not in S10 and S100. S100 showed significantly higher total glutathione peroxidase activity and glutathione S-transferase activity in liver compared to C (p < 0.05). In conclusion, sesamin may enhance LPO degradation in the liver resulting in the strong protective effects against exercise-induced plasma lipid peroxidation.Entities:
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Year: 2003 PMID： 12968212 DOI： 10.1055/s-2003-42010
Source DB: PubMed Journal: Int J Sports Med ISSN： 0172-4622 Impact factor: 3.118