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Literature DB >> 12967299

Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates.

Thorsten A Kirschberg¹, Chris L VanDeusen, Jonathan B Rothbard, Michael Yang, Paul A Wender.

Abstract

[structure: see text] A flexible and efficient procedure has been developed for the conjugation of taxol to various arginine-based molecular transporters via the taxol C2' O-chloroacetyl derivative. The resultant taxol-transporter conjugates are highly water soluble and release free taxol with half-lives of minutes to hours depending on the pH and the linker structure.

Entities: Chemical

Mesh：

Substances：

Year: 2003 PMID： 12967299 DOI： 10.1021/ol035234c

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

11 in total

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4. Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice.

Authors: Paul A Wender; Elena A Goun; Lisa R Jones; Thomas H Pillow; Jonathan B Rothbard; Rajesh Shinde; Christopher H Contag
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Review 6. Protacs for treatment of cancer.

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Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates.

Review 1. The design of guanidinium-rich transporters and their internalization mechanisms.

2. Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer.

Review 3. Cell penetrating peptides: overview and applications to the delivery of oligonucleotides.

4. Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice.

5. Calcium condensed LABL-TAT complexes effectively target gene delivery to ICAM-1 expressing cells.

Review 6. Protacs for treatment of cancer.

Review 7. Scratching the Surface: Resurfacing Proteins to Endow New Properties and Function.

Review 8. Cell-penetrating, guanidinium-rich molecular transporters for overcoming efflux-mediated multidrug resistance.

9. Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells.

Review 10. Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides.