Literature DB >> 12967296

Efficient synthesis of B-alkylated oxazaborolidines derived from ephedrine and norephedrine.

Margarita Ortiz-Marciales1, Eduvigis González, Melvin De Jesús, Sandraliz Espinosa, Wildeliz Correa, Johanna Martínez, Ruth Figueroa.   

Abstract

[reaction: see text] Representative B-butyl- and B-methyl-1,3,2-oxazaborolidines derived from ephedrine and norephedrine were prepared in good yield and excellent purity by one-pot treatment of B-H oxazaborolidines with the corresponding organolithium reagent and subsequent hydrolysis of the cyclic borohydride intermediate with anhydrous ammonium chloride.

Entities:  

Mesh:

Substances:

Year:  2003        PMID: 12967296      PMCID: PMC2811074          DOI: 10.1021/ol0352153

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

1.  Highly Enantioenriched Propargylic Alcohols by Oxazaborolidine-Mediated Reduction of Acetylenic Ketones.

Authors:  Jordi Bach; Ramon Berenguer; Jordi Garcia; Teresa Loscertales; Jaume Vilarrasa
Journal:  J Org Chem       Date:  1996-12-13       Impact factor: 4.354

Review 2.  Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method.

Authors:  Elias J Corey; Christopher J Helal
Journal:  Angew Chem Int Ed Engl       Date:  1998-08-17       Impact factor: 15.336

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.