BACKGROUND: Among genetic and biopsychological factors involved in alcohol-dependence vulnerability, dopamine receptor subtypes genes and temperament's dimensions, such as sensation seeking, have been particularly incriminated. Moreover, it is suggested that higher levels of sensation seeking could be associated with a modification of sensitivity to dopamine in postsynaptic receptors. METHODS: We investigated whether the DRD1 DdeI polymorphism could be associated with the sensation-seeking level among a sample of 72 alcohol-dependent male and female patients. Analyses of variance were performed to test for an effect between the DRD1 DdeI genotypes and sensation-seeking scores according to the 40-item Zuckerman scale. RESULTS: When comparing the DRD1 DdeI genotypes and the Zuckerman scores, we found a significant association only in men (p = 0.01). CONCLUSIONS: That is the first report of a male limited association between the DRD1 gene polymorphism and sensation-seeking score in alcohol-dependent subjects.
BACKGROUND: Among genetic and biopsychological factors involved in alcohol-dependence vulnerability, dopamine receptor subtypes genes and temperament's dimensions, such as sensation seeking, have been particularly incriminated. Moreover, it is suggested that higher levels of sensation seeking could be associated with a modification of sensitivity to dopamine in postsynaptic receptors. METHODS: We investigated whether the DRD1 DdeI polymorphism could be associated with the sensation-seeking level among a sample of 72 alcohol-dependent male and female patients. Analyses of variance were performed to test for an effect between the DRD1 DdeI genotypes and sensation-seeking scores according to the 40-item Zuckerman scale. RESULTS: When comparing the DRD1 DdeI genotypes and the Zuckerman scores, we found a significant association only in men (p = 0.01). CONCLUSIONS: That is the first report of a male limited association between the DRD1 gene polymorphism and sensation-seeking score in alcohol-dependent subjects.
Authors: Katelyn A Carr; Henry Lin; Kelly D Fletcher; Lara Sucheston; Prashant K Singh; Robbert J Salis; Richard W Erbe; Myles S Faith; David B Allison; Eric Stice; Leonard H Epstein Journal: Behav Neurosci Date: 2013-04-01 Impact factor: 1.912
Authors: O Levran; D Londono; K O'Hara; M Randesi; J Rotrosen; P Casadonte; S Linzy; J Ott; M Adelson; M J Kreek Journal: Genes Brain Behav Date: 2009-06-20 Impact factor: 3.449
Authors: Shahidee Zainal Abidin; Eng Liang Tan; Soon-Choy Chan; Ameerah Jaafar; Alex Xuen Lee; Mohd Hamdi Noor Abd Hamid; Nor Azian Abdul Murad; Nur Fadlina Pakarul Razy; Shahrul Azmin; Azlina Ahmad Annuar; Shen Yang Lim; Pike-See Cheah; King-Hwa Ling; Norlinah Mohamed Ibrahim Journal: BMC Neurol Date: 2015-04-22 Impact factor: 2.474
Authors: Kristin M Pearson-Fuhrhop; Brian Minton; Daniel Acevedo; Babak Shahbaba; Steven C Cramer Journal: PLoS One Date: 2013-04-17 Impact factor: 3.240