Two different types of Y cells in the cat lateral geniculate nucleus.

The Y pathway in the cat visual system is traditionally viewed as a single channel that originates in the retina. However, most Y cells from the contralateral retina diverge to innervate two different layers of the lateral geniculate nucleus, suggesting a possible channel split: YC (Y geniculate cell in layer C) and YA (Y geniculate cell in layer A). We tested the functional significance of this anatomical divergence by comparing the response properties of simultaneously recorded YC and YA geniculate cells with overlapping receptive fields. Our results demonstrate that YC and YA cells significantly differ in a large number of temporal and spatial parameters including response latency, response transiency, receptive-field size, and linearity of spatial summation. Furthermore, for some of these parameters, the differences between YC and YA cells are as pronounced as the differences between Y and X cells in layer A. These results along with results from previous studies strongly suggest that Y retinal afferents diverge into two separate channels at the level of the thalamus.