| Literature DB >> 12965897 |
Denise Bertulucci Rocha-Rodrigues1, Giovana Paschoini, Sanivia Aparecida Lima Pereira, Marlene Antonia dos Reis, Vicente de Paula Antunes Teixeira, Virmondes Rodrigues Júnior.
Abstract
Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response.Entities:
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Year: 2003 PMID: 12965897 PMCID: PMC193914 DOI: 10.1128/cdli.10.5.741-743.2003
Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN: 1071-412X