| Literature DB >> 12965246 |
Anete Curte Ferraz1, Léder Leal Xavier, Sílvia Hernandes, Martha Sulzbach, Giordano Gubert Viola, Janete A Anselmo-Franci, Matilde Achaval, Claudio Da Cunha.
Abstract
The immunostaining for tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNpc) and in the ventral tegmental area (VTA) after intranigral infusion of 6-hydroxydopamine (6-OHDA, 6 microg/side) was analyzed in ovariectomized adult female Wistar rats. Estrogen replacement for 52 days (400-microg 17-beta-estradiol capsules) did not prevent the loss of TH-immunoreactive cells induced by 6-OHDA in the SNpc. This result indicates that the neuroprotective effect of dopaminergic mesencephalic cells is not observed with long-term estrogen replacement.Entities:
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Year: 2003 PMID： 12965246 DOI： 10.1016/s0006-8993(03)03198-6
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252