BACKGROUND: UV radiation is a risk factor for nonmelanoma skin cancer (NMSC). The relation between DNA damage and oncogenesis suggests that diminished DNA repair capacity (DRC) is involved in tumorigenesis. OBJECTIVE: The purpose of this study was to test the hypothesis that a low DRC is a susceptibility factor for the development of NMSC in Puerto Rico. METHODS: A case-control retrospective clinical study was done to compare the age-adjusted DRC in participants with and without NMSC. DRC was measured using a host cell reactivation assay with a luciferase reporter gene irradiated with UV light and transfected into human peripheral lymphocytes. An epidemiologic questionnaire was used to solicit risk factors. RESULTS: The mean (+/-2 SE) DRC of 177 control patients without skin cancer was 8.6% +/- 0.7. Participants (280) with NMSC had a 42% lower DRC (5.0% +/- 0.3). CONCLUSION: A low DRC is a susceptibility factor for NMSC.
BACKGROUND: UV radiation is a risk factor for nonmelanoma skin cancer (NMSC). The relation between DNA damage and oncogenesis suggests that diminished DNA repair capacity (DRC) is involved in tumorigenesis. OBJECTIVE: The purpose of this study was to test the hypothesis that a low DRC is a susceptibility factor for the development of NMSC in Puerto Rico. METHODS: A case-control retrospective clinical study was done to compare the age-adjusted DRC in participants with and without NMSC. DRC was measured using a host cell reactivation assay with a luciferase reporter gene irradiated with UV light and transfected into human peripheral lymphocytes. An epidemiologic questionnaire was used to solicit risk factors. RESULTS: The mean (+/-2 SE) DRC of 177 control patients without skin cancer was 8.6% +/- 0.7. Participants (280) with NMSC had a 42% lower DRC (5.0% +/- 0.3). CONCLUSION: A low DRC is a susceptibility factor for NMSC.
Authors: Nicola Machella; Mary Beth Terry; Jennifer Zipprich; Irina Gurvich; Yuyan Liao; Ruby T Senie; David O Kennedy; Regina M Santella Journal: Carcinogenesis Date: 2008-06-19 Impact factor: 4.944
Authors: Rick J Jansen; Sharon Fonseca-Williams; William R Bamlet; Sylvette Ayala-Peña; Ann L Oberg; Gloria M Petersen; Carlos A Torres-Ramos Journal: Mol Carcinog Date: 2014-08-11 Impact factor: 4.784
Authors: Li-E Wang; Zhibin Hu; Erich M Sturgis; Margaret R Spitz; Sara S Strom; Christopher I Amos; Zhaozheng Guo; Yawei Qiao; Ann Marie Gillenwater; Jeffrey N Myers; Gary L Clayman; Randal S Weber; Adel K El-Naggar; Li Mao; Scott M Lippman; Waun Ki Hong; Qingyi Wei Journal: Clin Cancer Res Date: 2010-01-12 Impact factor: 12.531