Literature DB >> 12963837

The role of p27Kip1 in proteasome inhibitor induced apoptosis.

Hannes C A Drexler1.   

Abstract

Proteasome inhibitors are potent inducers of cell death. The cytotoxic effect of proteasome inhibitors in general appears to be selective for proliferating cells, while quiescent cells seem to be protected. Conflicting results have been reported on the role of the CKI p27Kip1 either in promoting or inhibiting apoptosis mediated by proteasome inhibitors and other drugs. Here I discuss the role of p27Kip1 in apoptosis and chemotherapy of cancer.

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Year:  2003        PMID： 12963837

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  12 in total

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Authors:  Aslamuzzaman Kazi; Adam Carie; Michelle A Blaskovich; Cynthia Bucher; Van Thai; Stacy Moulder; Hairuo Peng; Dora Carrico; Erin Pusateri; Warren J Pledger; Norbert Berndt; Andrew Hamilton; Saïd M Sebti
Journal:  Mol Cell Biol       Date:  2009-02-09       Impact factor: 4.272

10.  Integrated genomic analysis of proteasome alterations across 11,057 patients with 33 cancer types: clinically relevant outcomes in framework of 3P medicine.

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Journal:  EPMA J       Date:  2021-09-30       Impact factor: 6.543
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