| Literature DB >> 12963830 |
Patrick Seale1, Anna Polesskaya, Michael A Rudnicki.
Abstract
Recently, we describe a biological role for endogenous CD45+ stem cells in maintaining muscle integrity by participating in regeneration. Our experiments further establish that Wnt-signaling is the mechanism by which resident CD45+ adult stem cells are induced to undergo myogenic specification during muscle regeneration. Importantly, our study suggests that targeting the Wnt-pathway represents a promising therapeutic approach for the treatment of neuromuscular degenerative diseases.Entities:
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Year: 2003 PMID： 12963830
Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534