| Literature DB >> 12963148 |
Seung-Heon Hong1, Hyun-Ja Jeong, Hyung-Min Kim.
Abstract
The effect of aqueous extract of Xanthii fructus (XF) on mast cell-mediated allergic reaction has been investigated. XF inhibited compound 48/80-induced systemic anaphylaxis in mouse. This dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. Additionally, XF inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylatic reaction. When XF (0.1mg/ml) was added, the secretion of tumor necrosis factor-alpha (TNF-alpha) from anti-dinitrophenyl (DNP) IgE antibody-stimulated mast cells was inhibited by 56%. Our studies provide evidence that XF may be beneficial in the treatment of various types allergic diseases.Entities:
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Year: 2003 PMID： 12963148 DOI： 10.1016/s0378-8741(03)00232-0
Source DB: PubMed Journal: J Ethnopharmacol ISSN： 0378-8741 Impact factor: 4.360