Literature DB >> 12963120

MnSOD polymorphism and breast cancer in a population-based case-control study.

Kathleen M Egan1, Patricia A Thompson, Linda Titus-Ernstoff, Jason H Moore, Christine B Ambrosone.   

Abstract

A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer. We evaluated this relationship in a population-based case-control study (476 breast cancer cases and 502 controls). Overall, relative risks were not significantly elevated in women with one (RR: 1.27; 95% CI: 0.91-1.77) or two (RR: 1.18; 95% CI: 0.81-1.73) Ala alleles compared to those homozygous for the wild-type Val genotype. Results do not support any overall association of the Ala-9Val MnSOD polymorphism to the development of breast cancer.

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Year:  2003        PMID： 12963120     DOI： 10.1016/s0304-3835(03)00349-5

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  18 in total

Review 1.  Superoxide dismutase 2 gene and cancer risk: evidence from an updated meta-analysis.

Authors:  Sang Wook Kang
Journal:  Int J Clin Exp Med       Date:  2015-09-15

2.  MnSOD and CAT polymorphisms modulate the effect of the Mediterranean diet on breast cancer risk among Greek-Cypriot women.

Authors:  Maria G Kakkoura; Christiana A Demetriou; Maria A Loizidou; Giorgos Loucaides; Ioanna Neophytou; Simon Malas; Kyriacos Kyriacou; Andreas Hadjisavvas
Journal:  Eur J Nutr       Date:  2015-07-01       Impact factor: 5.614

3.  Increased risk of advanced prostate cancer associated with MnSOD Ala-9-Val gene polymorphism.

Authors:  Canan Kucukgergin; Oner Sanli; Tzevat Tefik; Makbule Aydın; Faruk Ozcan; Sule Seckin
Journal:  Mol Biol Rep       Date:  2011-05-08       Impact factor: 2.316

4.  There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival.

Authors:  Chengdi Wang; Yang Liu; Jian Zhou; Lei Ye; Nan Chen; Min Zhu; Yulin Ji
Journal:  Mol Clin Oncol       Date:  2017-08-14

5.  Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin.

Authors:  Dede N Ekoue; Soumen Bera; Emmanuel Ansong; Peter C Hart; Sofia Zaichick; Frederick E Domann; Marcelo G Bonini; Alan M Diamond
Journal:  Free Radic Res       Date:  2017-07-04

6.  Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study.

Authors:  D Craig Willcox; Bradley J Willcox; Wen-Chi Hsueh; Makoto Suzuki
Journal:  Age (Dordr)       Date:  2006-12-08

Review 7.  The structure-function relationships and physiological roles of MnSOD mutants.

Authors:  Rosalin Bonetta Valentino
Journal:  Biosci Rep       Date:  2022-06-30       Impact factor: 3.976

8.  Alcohol consumption and breast tumor mitochondrial DNA mutations.

Authors:  Mary E Platek; Peter G Shields; Duanjun Tan; Catalin Marian; Matthew R Bonner; Susan E McCann; Jing Nie; Gregory E Wilding; Christine Ambrosone; Amy E Millen; Maurizio Trevisan; Marcia Russell; Thomas H Nochajski; Stephen B Edge; Janet Winston; Jo L Freudenheim
Journal:  Breast Cancer Res Treat       Date:  2009-10-22       Impact factor: 4.872

9.  Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress.

Authors:  Hezhongrong Nie; Guorong Chen; Jing He; Fengjiao Zhang; Ming Li; Qiufeng Wang; Huaibin Zhou; Jianxin Lyu; Yidong Bai
Journal:  Mitochondrion       Date:  2015-12-08       Impact factor: 4.160

10.  MnSOD gene polymorphism association with steroid-dependent cancer.

Authors:  Claudia Giuliano Bica; Leonardo Leiria de Moura da Silva; Nadima Vieira Toscani; Ivana Beatrice Manica da Cruz; Gustavo Sá; Márcia Silveira Graudenz; Cláudio Galleano Zettler
Journal:  Pathol Oncol Res       Date:  2008-06-14       Impact factor: 3.201
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