Temporal visual filtering in diabetes mellitus.

The background modulation method was used to investigate the temporal response of the magnocellular pathway in diabetic patients and controls. The luminance threshold for detecting a moving, 2 degrees, achromatic target was measured as a function of background flicker frequency from 5 to 45 Hz. A model of photoreceptor kinetics integrated with difference of Gaussian receptive fields [Vis. Neurosci. 13 (1996) 173] was used to analyse the data. Diabetic patients with significant maculopathy showed raised thresholds at 8.75, 12.5, 15 and 17.5 Hz. Estimates of photoreceptor summation time were the same in both groups, but receptive field centre-to-surround delay showed an increasing trend in the diabetic patients.