OBJECTIVE: To evaluate the effect of thiazolidinediones on the development of cardiac failure and pulmonary edema during treatment of type 2 diabetes mellitus. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 6 men (aged 66 to 78 years) treated at our institution between August 1, 2001, and May 21, 2002, who had type 2 diabetes and developed signs and symptoms of congestive heart failure and pulmonary edema after 1 to 16 months of therapy with pioglitazone or rosiglitazone. RESULTS: Four patients had chronic renal insufficiency; only 1 had ischemic cardiomyopathy. Symptoms resolved promptly in all 6 patients after administration of diuretics and discontinuation of the thiazolidinedione. CONCLUSION: We conclude that thiazolidinediones can cause or exacerbate heart failure and pulmonary edema and should be avoided in patients with left ventricular dysfunction or chronic renal insufficiency.
OBJECTIVE: To evaluate the effect of thiazolidinediones on the development of cardiac failure and pulmonary edema during treatment of type 2 diabetes mellitus. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 6 men (aged 66 to 78 years) treated at our institution between August 1, 2001, and May 21, 2002, who had type 2 diabetes and developed signs and symptoms of congestive heart failure and pulmonary edema after 1 to 16 months of therapy with pioglitazone or rosiglitazone. RESULTS: Four patients had chronic renal insufficiency; only 1 had ischemic cardiomyopathy. Symptoms resolved promptly in all 6 patients after administration of diuretics and discontinuation of the thiazolidinedione. CONCLUSION: We conclude that thiazolidinediones can cause or exacerbate heart failure and pulmonary edema and should be avoided in patients with left ventricular dysfunction or chronic renal insufficiency.
Authors: Li Zhou; Gang Liu; Zhanjun Jia; Kevin T Yang; Ying Sun; Yutaka Kakizoe; Mi Liu; Shufeng Zhou; Ren Chen; Baoxue Yang; Tianxin Yang Journal: Am J Physiol Renal Physiol Date: 2013-09-04
Authors: Fadia T Shaya; James Y Shin; Daniel Mullins; Hugh O Fatodu; Anna Gu; Elijah Saunders Journal: J Natl Med Assoc Date: 2005-04 Impact factor: 1.798
Authors: Michel Komajda; John J V McMurray; Henning Beck-Nielsen; Ramon Gomis; Markolf Hanefeld; Stuart J Pocock; Paula S Curtis; Nigel P Jones; Philip D Home Journal: Eur Heart J Date: 2010-01-29 Impact factor: 29.983