Literature DB >> 12962141

Phorbol esters induce translocation of the nPKC p105 to membrane in mussel hemocytes.

Luís Mercado1, Asunción Cao, Ramiro Barcia, Juan Ignacio Ramos-Martinez.   

Abstract

Previous works revealed the presence of the nPKC enzyme p105 in hemocytes of M. galloprovincialis Lmk. Specific mussel antibodies were obtained from mouse and used in confocal microscopy and Western blotting. These techniques allowed the observation of p105 cytosol-to-membrane translocation induced by TPA for the first time in hemocytes of molluscs. The incubation of mussel immune cells with TPA for longer than 30 min also triggered a down-regulation process. Mussel hemocytes are an excellent model to study the molecular processes of innate immunity.

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Year:  2003        PMID： 12962141     DOI： 10.1023/a:1024981814050

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  17 in total

1.  The IL-2 receptor in hemocytes of the sea mussel Mytilus galloprovincialis Lmk.

Authors:  R Barcia; A Cao; J Arbeteta; J I Ramos-Martinez
Journal:  IUBMB Life       Date:  1999-10       Impact factor: 3.885

Review 2.  Toll-like receptors in the induction of the innate immune response.

Authors:  A Aderem; R J Ulevitch
Journal:  Nature       Date:  2000-08-17       Impact factor: 49.962

3.  Cloning and characterization of Ca(2+)-dependent and Ca(2+)-independent PKCs expressed in Aplysia sensory cells.

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Journal:  J Neurosci       Date:  1991-08       Impact factor: 6.167

Review 4.  The neuroimmunology of stress from invertebrates to man.

Authors:  E Ottaviani; C Franceschi
Journal:  Prog Neurobiol       Date:  1996 Mar-Apr       Impact factor: 11.685

5.  Identification of protein kinase C isoforms in marine mussels.

Authors:  R Barcia; J M Lopez-Garcia; J E Girardini; J I Ramos-Martinez
Journal:  Biochem Mol Biol Int       Date:  1997-09

Review 6.  New insights into the regulation of protein kinase C and novel phorbol ester receptors.

Authors:  D Ron; M G Kazanietz
Journal:  FASEB J       Date:  1999-10       Impact factor: 5.191

7.  The C2 domain of the Ca(2+)-independent protein kinase C Apl II inhibits phorbol ester binding to the C1 domain in a phosphatidic acid-sensitive manner.

Authors:  A M Pepio; W S Sossin
Journal:  Biochemistry       Date:  1998-02-03       Impact factor: 3.162

8.  Membrane translocation of novel protein kinase Cs is regulated by phosphorylation of the C2 domain.

Authors:  A M Pepio; W S Sossin
Journal:  J Biol Chem       Date:  2000-11-09       Impact factor: 5.157

Review 9.  The sevenfold way of PKC regulation.

Authors:  W S Liu; C A Heckman
Journal:  Cell Signal       Date:  1998-09       Impact factor: 4.315

10.  Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Authors:  M Castagna; Y Takai; K Kaibuchi; K Sano; U Kikkawa; Y Nishizuka
Journal:  J Biol Chem       Date:  1982-07-10       Impact factor: 5.157
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  2 in total

1.  Purification and characterization of a new Ca2+-dependent protein kinase C in mussel (Mytilus galloprovincialis Lmk.) mantle.

Authors:  M Gonzalez-Riopedre; R Barcia; J I Ramos-Martínez
Journal:  Mol Cell Biochem       Date:  2009-02-13       Impact factor: 3.396

2.  The Ca2+-independent PKC (p105) mediates the PMA-activation of marine mussel hemocytes and the Ca2+-dependent PKC (p60) does not intervene.

Authors:  M Gonzalez-Riopedre; R Barcia; J I Ramos-Martínez
Journal:  Mol Cell Biochem       Date:  2009-07-07       Impact factor: 3.396
  2 in total

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