Literature DB >> 12961098

Ghrelin plasmatic levels in patients with fibromyalgia.

Miguel Otero1, Ruben Nogueiras, Francisca Lago, Juan Meijide, Juan Amarelo, Antonio Mera, Juan Gomez-Reino, Oreste Gualillo.   

Abstract

Ghrelin is a recently discovered 28 amino acid peptide that regulates GH secretion and energy homeostasis. In fibromyalgia (FM) there are alterations in the pituitary-hypothalamic axis, particularly in the growth hormone (GH) secretion pattern. Whether this anomalous secretion of GH pertains to abnormal levels of ghrelin is still unknown. The purpose of this study was to investigate plasma ghrelin levels in patients with fibromyalgia (FM) compared with healthy controls. Plasmatic ghrelin concentrations were determined by a double antibody radioimmunoassay in 19 patients with FM and 14 healthy controls. Compared with controls, patients with FM did not show any significant differences of ghrelin plasmatic levels. In conclusion, FM is not associated with deviation in ghrelin concentrations. Existing alterations in FM with respect to GH are unlikely due to circulating ghrelin.

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Year:  2003        PMID： 12961098     DOI： 10.1007/s00296-003-0390-4

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  15 in total

1.  Neuroendocrine correlates of chronic fatigue syndrome: a brief review.

Authors:  M A Demitrack
Journal:  J Psychiatr Res       Date:  1997 Jan-Feb       Impact factor: 4.791

Review 2.  [Hormonal perturbations in fibromyalgia].

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Journal:  Ann Endocrinol (Paris)       Date:  2001-12       Impact factor: 2.478

3.  Low growth hormone secretion in patients with fibromyalgia--a preliminary report on 10 patients and 10 controls.

Authors:  E Bagge; B A Bengtsson; L Carlsson; J Carlsson
Journal:  J Rheumatol       Date:  1998-01       Impact factor: 4.666

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Journal:  Eur J Endocrinol       Date:  2000-12       Impact factor: 6.664

5.  The growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-1 axis in patients with fibromyalgia syndrome.

Authors:  A Leal-Cerro; J Povedano; R Astorga; M Gonzalez; H Silva; F Garcia-Pesquera; F F Casanueva; C Dieguez
Journal:  J Clin Endocrinol Metab       Date:  1999-09       Impact factor: 5.958

6.  Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

Authors:  M Kojima; H Hosoda; Y Date; M Nakazato; H Matsuo; K Kangawa
Journal:  Nature       Date:  1999-12-09       Impact factor: 49.962

Review 7.  The fibromyalgia syndrome as a manifestation of neuroticism?

Authors:  P Netter; J Hennig
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Authors:  H Moldofsky
Journal:  Baillieres Clin Rheumatol       Date:  1994-11

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Authors:  F Wolfe; H A Smythe; M B Yunus; R M Bennett; C Bombardier; D L Goldenberg; P Tugwell; S M Campbell; M Abeles; P Clark
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10.  Insulin-like growth factor-I (somatomedin C) levels in chronic fatigue syndrome and fibromyalgia.

Authors:  D Buchwald; J Umali; M Stene
Journal:  J Rheumatol       Date:  1996-04       Impact factor: 4.666
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  2 in total

Review 1.  Growth hormone in musculoskeletal pain states.

Authors:  Robert Bennett
Journal:  Curr Rheumatol Rep       Date:  2004-08       Impact factor: 4.592

Review 2.  Growth hormone in musculoskeletal pain states.

Authors:  Robert Bennett
Journal:  Curr Pain Headache Rep       Date:  2005-10
  2 in total

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