OBJECTIVE: The present study was aimed at examining the association between the -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder (MDD) in the Korean population. METHODS: One hundred and eight in-patients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Genotype and allele distributions in patients with MDD (P=0.024 and P=0.0125, respectively), were significantly different from those of the controls. In particular, subjects with MDD had an increased frequency of the TNF2 (A) allele. CONCLUSION: The present study suggests that the -G308A tumour necrosis factor-alpha gene polymorphism may have a potential role for susceptibility to MDD in the Korean population.
OBJECTIVE: The present study was aimed at examining the association between the -G308Atumour necrosis factor-alpha gene polymorphism and major depressive disorder (MDD) in the Korean population. METHODS: One hundred and eight in-patients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Genotype and allele distributions in patients with MDD (P=0.024 and P=0.0125, respectively), were significantly different from those of the controls. In particular, subjects with MDD had an increased frequency of the TNF2 (A) allele. CONCLUSION: The present study suggests that the -G308Atumour necrosis factor-alpha gene polymorphism may have a potential role for susceptibility to MDD in the Korean population.
Authors: Rushaniya A Khairova; Rodrigo Machado-Vieira; Jing Du; Husseini K Manji Journal: Int J Neuropsychopharmacol Date: 2009-02-19 Impact factor: 5.176
Authors: Tanel Traks; Kati Koido; Triin Eller; Eduard Maron; Külli Kingo; Veiko Vasar; Eero Vasar; Sulev Kõks Journal: BMC Med Genet Date: 2008-12-16 Impact factor: 2.103