OBJECTIVE: Disturbances in catecholamine transmission have been implicated in schizophrenia. Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells. We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for association with schizophrenia. METHODS: Unrelated schizophrenic patients (n=155) and control subjects (n=436) were analysed with regard to the DBH -1021 C/T variant. RESULTS: No significant allele or genotype differences were found. CONCLUSIONS: The present results do not support a major involvement of the DBH gene in schizophrenia in the Swedish population investigated.
OBJECTIVE: Disturbances in catecholamine transmission have been implicated in schizophrenia. Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells. We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for association with schizophrenia. METHODS: Unrelated schizophrenicpatients (n=155) and control subjects (n=436) were analysed with regard to the DBH-1021 C/T variant. RESULTS: No significant allele or genotype differences were found. CONCLUSIONS: The present results do not support a major involvement of the DBH gene in schizophrenia in the Swedish population investigated.
Authors: Erik G Jönsson; Jessica Bah; Jonas Melke; Rami Abou Jamra; Johannes Schumacher; Lars Westberg; Roland Ivo; Sven Cichon; Peter Propping; Markus M Nöthen; Elias Eriksson; Göran C Sedvall Journal: BMC Psychiatry Date: 2004-03-04 Impact factor: 3.630