| Literature DB >> 12960383 |
Gabriella Pietra1, Chiara Romagnani, Paola Mazzarino, Michela Falco, Enrico Millo, Alessandro Moretta, Lorenzo Moretta, Maria Cristina Mingari.
Abstract
HLA-E-restricted T cell receptor alphabeta+ CD8+ cytolytic T lymphocytes (CTLs) exist as monoclonal expansions in the peripheral blood of some individuals. Here, we show that they recognize, with high avidity, peptides derived from the UL40 protein of different human cytomegalovirus (CMV) strains. Recognition results in the induction of cytotoxicity, IFN-gamma production and cell proliferation. Autologous cells pulsed with CMV-derived peptides become susceptible to lysis by HLA-E-restricted CTLs and induce their proliferation. The high avidity for CMV-derived peptides may explain how these cells are generated in vivo and suggest their possible role in the host defenses against CMV, a virus that evolved various mechanisms to down-regulate classical HLA class I molecules, thus escaping detection by conventional CTLs.Entities:
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Year: 2003 PMID： 12960383 PMCID： PMC196899 DOI： 10.1073/pnas.1834449100
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205