Literature DB >> 12959888

MDI Exposure for Spray-On Truck Bed Lining.

Don J Lofgren1, Terry L Walley, Phillip M Peters, Marty L Weis.   

Abstract

Worker exposure to MDI (methylenediphenyl isocyanate) in the sprayed-on truck bed lining industry was assessed by examining Washington State OSHA inspection files and industrial insurance records. The industry uses MDI to form a protective urethane coating on pick-up truck beds. The lining is applied by a worker using a handheld spray gun with application equipment at temperatures and pressures specified by the urethane supplier. Inspections with MDI sampling were initially identified by searching the agency's laboratory database and were further screened for the targeted process. Data for 13 employers was found and extracted from the inspection records. All were small companies with only 1 to 2 workers exposed to MDI; 10 of the 13 employers had started the bed lining service within the last 4 years. The process was found in truck bed lining specialty shops as well as in other truck-related businesses. Six different urethane products were used with reported MDI monomer concentrations of up to 75 percent along with varying concentrations of MDI pre-polymers and other reactants and solvents. Sampling for MDI by inspectors found 7 worksites with worker exposure in excess of the state and OSHA ceiling limit of 0.200 mg/M(3). Deficiencies in respirator programs and engineering controls for MDI were cited. A review of the industrial insurance records found a total of five MDI-related claims at 4 inspected worksites, two for new-onset asthma. It was concluded that workers in the urethane sprayed-on truck bed lining industry are at an increased risk of developing illnesses associated with isocyanate exposure. Interventions are needed to further assess the hazard as well as motivate and assist franchisers, distributors, and retailers to implement effective engineering controls and respiratory protection programs in this nationally emerging small employer industry.

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Year:  2003        PMID: 12959888     DOI: 10.1080/10473220301441

Source DB:  PubMed          Journal:  Appl Occup Environ Hyg        ISSN: 1047-322X


  8 in total

1.  A murine monoclonal antibody with broad specificity for occupationally relevant diisocyanates.

Authors:  Angela R Lemons; Paul D Siegel; Morgen Mhike; Brandon F Law; Justin M Hettick; Toni A Bledsoe; Ajay P Nayak; Donald H Beezhold; Brett J Green
Journal:  J Occup Environ Hyg       Date:  2014       Impact factor: 2.155

2.  Molecular determinants of humoral immune specificity for the occupational allergen, methylene diphenyl diisocyanate.

Authors:  Adam V Wisnewski; Jian Liu
Journal:  Mol Immunol       Date:  2013-01-04       Impact factor: 4.407

3.  Biological monitoring of workers exposed to 4,4'-methylenediphenyl diisocyanate (MDI) in 19 French polyurethane industries.

Authors:  A Robert; P Ducos; J M Francin; P Marsan
Journal:  Int Arch Occup Environ Health       Date:  2006-10-24       Impact factor: 3.015

4.  Acute 4,4'-Methylene Diphenyl Diisocyanate Exposure-Mediated Downregulation of miR-206-3p and miR-381-3p Activates Inducible Nitric Oxide Synthase Transcription by Targeting Calcineurin/NFAT Signaling in Macrophages.

Authors:  Chen-Chung Lin; Brandon F Law; Justin M Hettick
Journal:  Toxicol Sci       Date:  2020-01-01       Impact factor: 4.849

5.  Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death.

Authors:  Adam V Wisnewski; Ryan Cooney; Michael Hodgson; Kristinza Giese; Jian Liu; Carrie A Redlich
Journal:  Am J Ind Med       Date:  2022-01-14       Impact factor: 2.214

6.  MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4'-methylene diphenyl diisocyanate exposed macrophages.

Authors:  Chen-Chung Lin; Brandon F Law; Justin M Hettick
Journal:  Xenobiotica       Date:  2021-12-02       Impact factor: 1.908

Review 7.  Use of population data for assessing trends in work-related asthma mortality.

Authors:  Jacek M Mazurek; Paul K Henneberger
Journal:  Curr Opin Allergy Clin Immunol       Date:  2019-04

8.  Prevention guidance for isocyanate-induced asthma using occupational surveillance data.

Authors:  Carolyn Reeb-Whitaker; Naomi J Anderson; David K Bonauto
Journal:  J Occup Environ Hyg       Date:  2013       Impact factor: 2.155

  8 in total

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