Literature DB >> 12959721

Molecular predictors of treatment and outcome in colorectal cancer.

Syma Iqbal1, Heinz-Josef Lenz.   

Abstract

Understanding of the metabolism and mechanisms of resistance of tumors to chemotherapeutic agents is essential so that we can administer therapy to maximize response and minimize toxicity. In this review we describe molecular markers associated with fluoropyrimidine and platinum-based chemotherapy that may predict the outcome of therapy when patients are treated with these agents. We discuss the ways in which determination of gene expression levels can enhance the treatment of colorectal cancer through prediction of patient response and tailoring of chemotherapy to the characteristics of an individual tumor.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12959721     DOI： 10.1007/s11894-003-0053-3

Source DB:  PubMed          Journal:  Curr Gastroenterol Rep        ISSN： 1522-8037


  27 in total

1.  Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers.

Authors:  K Kawakami; K Omura; E Kanehira; Y Watanabe
Journal:  Anticancer Res       Date:  1999 Jul-Aug       Impact factor: 2.480

2.  Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

Authors:  D Salonga; K D Danenberg; M Johnson; R Metzger; S Groshen; D D Tsao-Wei; H J Lenz; C G Leichman; L Leichman; R B Diasio; P V Danenberg
Journal:  Clin Cancer Res       Date:  2000-04       Impact factor: 12.531

3.  p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site.

Authors:  H J Lenz; K D Danenberg; C G Leichman; B Florentine; P G Johnston; S Groshen; L Zhou; Y P Xiong; P V Danenberg; L P Leichman
Journal:  Clin Cancer Res       Date:  1998-05       Impact factor: 12.531

4.  Relationship between intratumoral dihydropyrimidine dehydrogenase activity and gene expression in human colorectal cancer.

Authors:  H Uetake; W Ichikawa; T Takechi; M Fukushima; Z Nihei; K Sugihara
Journal:  Clin Cancer Res       Date:  1999-10       Impact factor: 12.531

5.  ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy.

Authors:  Y Shirota; J Stoehlmacher; J Brabender; Y P Xiong; H Uetake; K D Danenberg; S Groshen; D D Tsao-Wei; P V Danenberg; H J Lenz
Journal:  J Clin Oncol       Date:  2001-12-01       Impact factor: 44.544

6.  Discrepancies between the gene expression, protein expression, and enzymatic activity of thymidylate synthase and dihydropyrimidine dehydrogenase in human gastrointestinal cancers and adjacent normal mucosa.

Authors:  S Miyamoto; A Ochiai; N Boku; A Ohtsu; M Tahara; S Yoshida; H Okabe; T Takechi; M Fukushima
Journal:  Int J Oncol       Date:  2001-04       Impact factor: 5.650

7.  Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy.

Authors:  C Aschele; D Debernardis; S Casazza; G Antonelli; G Tunesi; C Baldo; R Lionetto; F Maley; A Sobrero
Journal:  J Clin Oncol       Date:  1999-06       Impact factor: 44.544

8.  Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin.

Authors:  C G Leichman; H J Lenz; L Leichman; K Danenberg; J Baranda; S Groshen; W Boswell; R Metzger; M Tan; P V Danenberg
Journal:  J Clin Oncol       Date:  1997-10       Impact factor: 44.544

9.  High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil.

Authors:  R Metzger; K Danenberg; C G Leichman; D Salonga; E L Schwartz; S Wadler; H J Lenz; S Groshen; L Leichman; P V Danenberg
Journal:  Clin Cancer Res       Date:  1998-10       Impact factor: 12.531

10.  Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.

Authors:  G J Peters; C L van der Wilt; C J van Groeningen; K Smid; S Meijer; H M Pinedo
Journal:  J Clin Oncol       Date:  1994-10       Impact factor: 44.544
View more
  1 in total

Review 1.  Multidisciplinary approach of colorectal liver metastases.

Authors:  I Juez; C Rubio; J Figueras
Journal:  Clin Transl Oncol       Date:  2011-10       Impact factor: 3.405
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.