Literature DB >> 12959154

Long-term recording of LTP in cultured hippocampal slices.

Ken Shimono1, Michel Baudry, Lam Ho, Makoto Taketani, Gary Lynch.   

Abstract

Long-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was completely and reversibly blocked by an antagonist of the NMDA receptor, APV. Our results suggest the possibility of using chronic recording in hippocampal slices cultured on multi-electrode arrays to study the mechanisms underlying LTP maintenance and stabilization.

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Year:  2002        PMID: 12959154      PMCID: PMC2565406          DOI: 10.1155/NP.2002.249

Source DB:  PubMed          Journal:  Neural Plast        ISSN: 1687-5443            Impact factor:   3.599


  17 in total

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