| Literature DB >> 12959154 |
Ken Shimono1, Michel Baudry, Lam Ho, Makoto Taketani, Gary Lynch.
Abstract
Long-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was completely and reversibly blocked by an antagonist of the NMDA receptor, APV. Our results suggest the possibility of using chronic recording in hippocampal slices cultured on multi-electrode arrays to study the mechanisms underlying LTP maintenance and stabilization.Mesh:
Substances:
Year: 2002 PMID: 12959154 PMCID: PMC2565406 DOI: 10.1155/NP.2002.249
Source DB: PubMed Journal: Neural Plast ISSN: 1687-5443 Impact factor: 3.599