Literature DB >> 12958216

Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway.

Srigiridhar Kotamraju1, Yoshiko Tampo, Agnes Keszler, Christopher R Chitambar, Joy Joseph, Arthur L Haas, B Kalyanaraman.   

Abstract

We investigated here the mechanism of cytoprotection of nitric oxide (*NO) in bovine aortic endothelial cells treated with H2O2. NONOates were used as *NO donors that released *NO slowly at a well defined rate in the extracellular and intracellular milieus. H2O2-mediated intracellular dichlorofluorescein fluorescence and apoptosis were enhanced by the transferrin receptor (TfR)-mediated iron uptake. *NO inhibited the TfR-mediated iron uptake, dichlorofluorescein fluorescence, and apoptosis in H2O2-treated cells. *NO increased the proteasomal activity and degradation of nitrated TfR via ubiquitination. Nomega-nitro-L-arginine methyl ester, a nonspecific inhibitor of endogenous *NO biosynthesis, decreased the trypsin-like activity of 26S proteasome. *NO, by activating proteolysis, mitigates TfR-dependent iron uptake, dichlorodihydrofluorescein oxidation, and apoptosis in H2O2-treated bovine aortic endothelial cells. The relevance of biological nitration on redox signaling is discussed.

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Year:  2003        PMID： 12958216      PMCID： PMC196859          DOI： 10.1073/pnas.1933581100

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  47 in total

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2.  The soluble "high potential" type iron-sulfur protein from mitochondria is aconitase.

Authors:  F J Ruzicka; H Beinert
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3.  Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.

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4.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

Authors:  J S Beckman; T W Beckman; J Chen; P A Marshall; B A Freeman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

5.  Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis.

Authors:  Srigiridhar Kotamraju; Christopher R Chitambar; Shasi V Kalivendi; Joy Joseph; B Kalyanaraman
Journal:  J Biol Chem       Date:  2002-02-20       Impact factor: 5.157

6.  Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction.

Authors:  Douglas D Thomas; Michael Graham Espey; Michael P Vitek; Katrina M Miranda; David A Wink
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7.  NCX-4016, a nitric oxide-releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial function.

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Review 8.  Mechanisms of hepatoprotection by nitric oxide.

Authors:  Yinna Wang; Yoram Vodovotz; Peter K M Kim; Ruben Zamora; Timothy R Billiar
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9.  Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endothelial cells: role of transferrin receptor-dependent iron uptake in apoptosis.

Authors:  Yoshiko Tampo; Srigiridhar Kotamraju; Christopher R Chitambar; Shasi V Kalivendi; Agnes Keszler; Joy Joseph; B Kalyanaraman
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10.  Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

Authors:  E A Leibold; H N Munro
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205
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  30 in total

1.  Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins.

Authors:  Anup Ramachandran; Erin Ceaser; Victor M Darley-Usmar
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-22       Impact factor: 11.205

2.  Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.

Authors:  Andrew M Pickering; Robert A Linder; Hongqiao Zhang; Henry J Forman; Kelvin J A Davies
Journal:  J Biol Chem       Date:  2012-02-03       Impact factor: 5.157

3.  S-nitrosoprotein formation and localization in endothelial cells.

Authors:  Yi Yang; Joseph Loscalzo
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-23       Impact factor: 11.205

4.  Antiretrovirals induce endothelial dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasia.

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Journal:  Toxicol Sci       Date:  2010-07-09       Impact factor: 4.849

5.  The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes.

Authors:  Andrew M Pickering; Alison L Koop; Cheryl Y Teoh; Gennady Ermak; Tilman Grune; Kelvin J A Davies
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6.  Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins.

Authors:  Choon-Myung Lee; Bong-Yoon Kim; Lian Li; Edward T Morgan
Journal:  J Biol Chem       Date:  2007-11-09       Impact factor: 5.157

7.  Iron increases the susceptibility of multiple myeloma cells to bortezomib.

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8.  Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q.

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9.  Effect of nitric oxide on naphthoquinone toxicity in endothelial cells: role of bioenergetic dysfunction and poly (ADP-ribose) polymerase activation.

Authors:  Katarzyna A Broniowska; Anne R Diers; John A Corbett; Neil Hogg
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10.  Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide.

Authors:  Sami Banerjee; Jaroslaw W Zmijewski; Emmanuel Lorne; Gang Liu; Yonggang Sha; Edward Abraham
Journal:  J Biol Chem       Date:  2009-11-20       Impact factor: 5.157
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