Literature DB >> 12957465

STAT-3 activity in chemically-induced hepatocellular carcinoma.

A Sánchez1, P Nagy, S S Thorgeirsson.   

Abstract

The signal transducer and activator of transcription (STAT)-3 regulates basic biological processes and it has been reported to be constitutively active in different types of malignant tumours. STAT-3 is active during the regenerative growth of the liver, but there are hardly any data about its presence in liver tumours. We investigated and found a high activity of STAT-3 using an electrophoretic mobility shift assay (EMSA) in chemically-induced rat hepatocellular carcinomas (HCCs). Dexamethasone treatment downregulated both STAT-3 activity and cell proliferation in the tumours. Therefore, the activity of the STAT-3 signal transduction pathway seems to be required for the growth of HCCs and could be a potential new target for therapeutic trials of this tumour type.

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Year:  2003        PMID： 12957465     DOI： 10.1016/s0959-8049(03)00393-9

Source DB:  PubMed          Journal:  Eur J Cancer        ISSN： 0959-8049            Impact factor:   9.162


  13 in total

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4.  Downregulated Expression of PTPN9 Contributes to Human Hepatocellular Carcinoma Growth and Progression.

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Journal:  Pathol Oncol Res       Date:  2015-12-29       Impact factor: 3.201

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Authors:  Xiao Tang Yu; Shi Neng Zhu; Zu De Xu; Xi Qi Hu; Teng Fang Zhu; Jie Qing Chen; Shi Lun Lu
Journal:  J Cancer Res Clin Oncol       Date:  2006-10-10       Impact factor: 4.553

6.  Altered p-STAT3 (tyr705) expression is associated with histological grading and intratumour microvessel density in hepatocellular carcinoma.

Authors:  Sheau-Fang Yang; Shen-Nien Wang; Chih-Fung Wu; Yao-Tsung Yeh; Chee-Yin Chai; Shih-Chang Chunag; Maw-Chang Sheen; King-Teh Lee
Journal:  J Clin Pathol       Date:  2006-08-10       Impact factor: 3.411

7.  Cloning and characterization of the human glutathione synthetase 5'-flanking region.

Authors:  Taunia D Lee; Heping Yang; Janet Whang; Shelly C Lu
Journal:  Biochem J       Date:  2005-09-01       Impact factor: 3.857

8.  Downregulation of GRIM-19 is associated with hyperactivation of p-STAT3 in hepatocellular carcinoma.

Authors:  Feifei Li; Wanhua Ren; Yanda Zhao; Zhaoqing Fu; Yongjian Ji; Yuhua Zhu; Chengyong Qin
Journal:  Med Oncol       Date:  2012-04-11       Impact factor: 3.064

9.  The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate.

Authors:  Ravi P Sahu; Sanjay K Srivastava
Journal:  J Natl Cancer Inst       Date:  2009-01-27       Impact factor: 13.506

10.  Comparative study of the effects of PEGylated interferon-α2a versus 5-fluorouracil on cancer stem cells in a rat model of hepatocellular carcinoma.

Authors:  Tarek Kamal Motawi; Noha Ahmed El-Boghdady; Abeer Mostafa El-Sayed; Hebatullah Samy Helmy
Journal:  Tumour Biol       Date:  2015-08-26
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