Literature DB >> 12956057

Convergent synthesis and preliminary biological evaluations of the stilbenolignan (+/-)-aiphanol and various congeners.

Martin G Banwell1, Anna Bezos, Satish Chand, Gerd Dannhardt, Werner Kiefer, Ulrike Nowe, Christopher R Parish, G Paul Savage, Holger Ulbrich.   

Abstract

Treatment of an equimolar mixture of stilbene 7 and cinnamyl alcohol 8 with silver carbonate in acetone-benzene afforded a ca. 2:1:2:1 mixture of the stilbenolignan (+/-)-aiphanol (1) and congeners 2-4 each of which show significant anti-angiogenic and COX-2 inhibitory properties.

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Year:  2003        PMID: 12956057     DOI: 10.1039/b305106d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  2 in total

Review 1.  Astonishing diversity of natural surfactants: 5. Biologically active glycosides of aromatic metabolites.

Authors:  Valery M Dembitsky
Journal:  Lipids       Date:  2005-09       Impact factor: 1.880

2.  Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2.

Authors:  Shanmei Chen; Junnan Feng; Chuanke Zhao; Lixin Wang; Lin Meng; Caiyun Liu; Shaoqing Cai; Yanxing Jia; Like Qu; Chengchao Shou
Journal:  Signal Transduct Target Ther       Date:  2021-12-03
  2 in total

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