Literature DB >> 1295544

In vitro antimicrobial activity of 18 phenothiazine derivatives: structure-activity relationship.

P Bourlioux1, J M Moreaux, W J Su, H Boureau.   

Abstract

The antimicrobial activity of 18 phenothiazine derivatives has been evaluated against aerobic and anaerobic bacteria. The mean of the MIC reveals five active drugs against the bacterial strains tested: thioridazine, chlorpromazine, trifluoperazine, fluphenazine and triflupromazine. The other derivatives are less active and some show no antimicrobial activity. It seems that in vitro antibacterial activity alone is insufficient to explain certain intestinal diseases linked to the use of these molecules in psychiatry.

Entities:  

Mesh:

Substances:

Year:  1992        PMID: 1295544

Source DB:  PubMed          Journal:  APMIS Suppl        ISSN: 0903-465X


  3 in total

1.  Cultivation in Space Flight Produces Minimal Alterations in the Susceptibility of Bacillus subtilis Cells to 72 Different Antibiotics and Growth-Inhibiting Compounds.

Authors:  Michael D Morrison; Patricia Fajardo-Cavazos; Wayne L Nicholson
Journal:  Appl Environ Microbiol       Date:  2017-10-17       Impact factor: 4.792

Review 2.  The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target.

Authors:  K Mazumdar; S G Dastidar; J H Park; N K Dutta
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2009-04-28       Impact factor: 3.267

Review 3.  Role of Phenothiazines and Structurally Similar Compounds of Plant Origin in the Fight against Infections by Drug Resistant Bacteria.

Authors:  Sujata G Dastidar; Jette E Kristiansen; Joseph Molnar; Leonard Amaral
Journal:  Antibiotics (Basel)       Date:  2013-02-18
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.