Literature DB >> 12954864

Molecular-imaging probe 2-(1-[6-[(2-fluoroethyl)(methyl) amino]-2-naphthyl]ethylidene) malononitrile labels prion plaques in vitro.

Mara Bresjanac1, Lojze M Smid, Tomaz D Vovko, Andrej Petric, Jorge R Barrio, Mara Popovic.   

Abstract

The study aimed to evaluate the fluorescent molecular-imaging probe 2-(1-[6-[(2-fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile (FDDNP) for its ability to selectively and reproducibly label prion plaques in fixed, paraffin-embedded cerebellar sections from patients of confirmed Gerstmann-Sträussler-Scheinker disease, sporadic Creutzfeldt-Jacob disease (CJD) with kuru plaques, and variant CJD (vCJD). FDDNP is a highly hydrophobic, viscosity-sensitive, solvent-sensitive, fluorescent substance, whose radiofluorinated analog [18F]FDDNP has recently been successfully used to label senile plaques and neurofibrillary tangles in the living brain of Alzheimer's disease patients with positron emission tomography. Our results show that FDDNP reliably identifies all prion plaques, including small cluster-plaques in vCJD. This finding may open new in vivo diagnostic possibilities for vCJD.

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Year:  2003        PMID： 12954864      PMCID： PMC6740487     

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  13 in total

1.  Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease.

Authors:  E D Agdeppa; V Kepe; J Liu; S Flores-Torres; N Satyamurthy; A Petric; G M Cole; G W Small; S C Huang; J R Barrio
Journal:  J Neurosci       Date:  2001-12-15       Impact factor: 6.167

Review 2.  Pathological diagnosis of variant Creutzfeldt-Jakob disease.

Authors:  J W Ironside; L McCardle; A Horsburgh; Z Lim; M W Head
Journal:  APMIS       Date:  2002-01       Impact factor: 3.205

3.  Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans.

Authors:  M R Scott; R Will; J Ironside; H O Nguyen; P Tremblay; S J DeArmond; S B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

4.  Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease.

Authors:  Kooresh Shoghi-Jadid; Gary W Small; Eric D Agdeppa; Vladimir Kepe; Linda M Ercoli; Prabha Siddarth; Stephen Read; Nagichettiar Satyamurthy; Andrej Petric; Sung-Cheng Huang; Jorge R Barrio
Journal:  Am J Geriatr Psychiatry       Date:  2002 Jan-Feb       Impact factor: 4.105

5.  Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health.

Authors:  C I Lasmézas; J G Fournier; V Nouvel; H Boe; D Marcé; F Lamoury; N Kopp; J J Hauw; J Ironside; M Bruce; D Dormont; J P Deslys
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-20       Impact factor: 11.205

6.  Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue.

Authors:  S A Schnell; W A Staines; M W Wessendorf
Journal:  J Histochem Cytochem       Date:  1999-06       Impact factor: 2.479

7.  IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques.

Authors:  Mei-Ping Kung; Catherine Hou; Zhi-Ping Zhuang; Bin Zhang; Daniel Skovronsky; John Q Trojanowski; Virginia M-Y Lee; Hank F Kung
Journal:  Brain Res       Date:  2002-11-29       Impact factor: 3.252

8.  The original Gerstmann-Sträussler-Scheinker family of Austria: divergent clinicopathological phenotypes but constant PrP genotype.

Authors:  J A Hainfellner; S Brantner-Inthaler; L Cervenáková; P Brown; T Kitamoto; J Tateishi; H Diringer; P P Liberski; H Regele; M Feucht
Journal:  Brain Pathol       Date:  1995-07       Impact factor: 6.508

9.  A new variant of Creutzfeldt-Jakob disease in the UK.

Authors:  R G Will; J W Ironside; M Zeidler; S N Cousens; K Estibeiro; A Alperovitch; S Poser; M Pocchiari; A Hofman; P G Smith
Journal:  Lancet       Date:  1996-04-06       Impact factor: 79.321

Review 10.  Imaging amyloid-beta deposits in vivo.

Authors:  Brian J Bacskai; William E Klunk; Chester A Mathis; Bradley T Hyman
Journal:  J Cereb Blood Flow Metab       Date:  2002-09       Impact factor: 6.200
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  20 in total

1.  Is amyloid plaque imaging the key to monitoring brain pathology of Alzheimer's disease in vivo?

Authors:  Agneta Nordberg
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-09-15       Impact factor: 9.236

2.  Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner.

Authors:  Yuri Kawasaki; Keiichi Kawagoe; Chun-jen Chen; Kenta Teruya; Yuji Sakasegawa; Katsumi Doh-ura
Journal:  J Virol       Date:  2007-09-19       Impact factor: 5.103

3.  High-yield, automated radiosynthesis of 2-(1-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile ([18F]FDDNP) ready for animal or human administration.

Authors:  Jie Liu; Vladimir Kepe; Alenka Zabjek; Andrej Petric; Henry C Padgett; Nagichettiar Satyamurthy; Jorge R Barrio
Journal:  Mol Imaging Biol       Date:  2007 Jan-Feb       Impact factor: 3.488

4.  Dicyanovinylnaphthalenes for neuroimaging of amyloids and relationships of electronic structures and geometries to binding affinities.

Authors:  Andrej Petric; Scott A Johnson; Hung V Pham; Ying Li; Simon Ceh; Amalija Golobic; Eric D Agdeppa; Gerald Timbol; Jie Liu; Gyochang Keum; Nagichettiar Satyamurthy; Vladimir Kepe; Kendall N Houk; Jorge R Barrio
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-25       Impact factor: 11.205

Review 5.  Amyloid Imaging: Poised for Integration into Medical Practice.

Authors:  Keshav Anand; Marwan Sabbagh
Journal:  Neurotherapeutics       Date:  2017-01       Impact factor: 7.620

6.  In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET.

Authors:  Nobuyuki Okamura; Yusei Shiga; Shozo Furumoto; Manabu Tashiro; Yoshio Tsuboi; Katsutoshi Furukawa; Kazuhiko Yanai; Ren Iwata; Hiroyuki Arai; Yukitsuka Kudo; Yasuhito Itoyama; Katsumi Doh-ura
Journal:  Eur J Nucl Med Mol Imaging       Date:  2009-12-17       Impact factor: 9.236

Review 7.  Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo.

Authors:  G D Rabinovici; W J Jagust
Journal:  Behav Neurol       Date:  2009       Impact factor: 3.342

8.  Molecular interactions of Alzheimer's biomarker FDDNP with Aβ peptide.

Authors:  Christopher Lockhart; Dmitri K Klimov
Journal:  Biophys J       Date:  2012-12-05       Impact factor: 4.033

9.  Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer's disease pathologies.

Authors:  Paul W Thompson; Liang Ye; Jennifer L Morgenstern; Lucia Sue; Thomas G Beach; Duncan J Judd; Nicholas J Shipley; Vincenzo Libri; Andrew Lockhart
Journal:  J Neurochem       Date:  2009-02-13       Impact factor: 5.372

Review 10.  Mapping brain beta-amyloid.

Authors:  William Jagust
Journal:  Curr Opin Neurol       Date:  2009-08       Impact factor: 5.710
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