Literature DB >> 1295376

Anti-inflammatory properties of zinc protoporphyrin disodium (Zn-PP-2Na).

H Nagai1, K Kitagaki, K Kuwabara, A Koda.   

Abstract

Anti-inflammatory properties of zinc protoporphyrin disodium (Zn-PP-2Na) were studied. Zn-PP-2Na exhibits anti-allergic action against type III and IV reactions (passive Arthus reaction in rats and tuberculin-induced footpad reaction in mice), but does not affect type I and II reactions (homologous passive cutaneous anaphylaxis in mice and reversed cutaneous anaphylaxis in rats). Zn-PP-2Na also clearly inhibits type II collagen-induced arthritis in mice. The agent inhibits general arthritis symptoms, anti-type-II collagen antibody production and type II collagen-induced delayed type hypersensitivity (DTH) in arthritic mice. Zn-PP-2Na, however, did not affect carrageenin-induced paw edema and histamine- and serotonin-induced skin reactions in rats. Zn-PP-2Na inhibits IL-1-induced mouse lymphocyte proliferation, but does not affect PMA-induced O2- generation from guinea-pig neutrophil. These results indicate that Zn-PP-2Na inhibits type II collagen-induced arthritis in mice due to the antagonism of IL-1 activity and the inhibition of DTH against type II collagen.

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Year:  1992        PMID： 1295376     DOI： 10.1007/bf02028120

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  21 in total

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Journal:  Arch Biochem Biophys       Date:  1985-09       Impact factor: 4.013
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  4 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-18       Impact factor: 11.205

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Journal:  Inflammation       Date:  1998-04       Impact factor: 4.092

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Authors:  H Nagai; Y Takaoka; H Mori; N Matsuura
Journal:  Inflamm Res       Date:  1996-06       Impact factor: 4.575

4.  Effects of copper and zinc on proteoglycan metabolism in articular cartilage.

Authors:  M Pasqualicchio; R Gasperini; G P Velo; M E Davies
Journal:  Mediators Inflamm       Date:  1996       Impact factor: 4.711
  4 in total

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