Literature DB >> 12952914

The host response to anthrax lethal toxin: unexpected observations.

Alice S Prince1.   

Abstract

Bacillus anthracis, the causative agent of anthrax, is believed to induce disease and death in humans in an endotoxic shock-like manner. A comprehensive study of the effects of anthrax toxin in mice demonstrates that toxin-induced death is mediated not by cytokine release, as previously thought, but by hypoxia-induced liver failure. The study strongly suggests that the therapies developed for treatment of cytokine-mediated septic shock will not be appropriate for the treatment of anthrax.

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Year:  2003        PMID： 12952914      PMCID： PMC182215          DOI： 10.1172/JCI19581

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  14 in total

Review 1.  Anthrax.

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Journal:  N Engl J Med       Date:  1999-09-09       Impact factor: 91.245

2.  Crystal structure of the anthrax toxin protective antigen.

Authors:  C Petosa; R J Collier; K R Klimpel; S H Leppla; R C Liddington
Journal:  Nature       Date:  1997-02-27       Impact factor: 49.962

3.  Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha.

Authors:  R Pellizzari; C Guidi-Rontani; G Vitale; M Mock; C Montecucco
Journal:  FEBS Lett       Date:  1999-11-26       Impact factor: 4.124

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Journal:  Am J Dermatopathol       Date:  1981       Impact factor: 1.533

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Authors:  S Shafazand; R Doyle; S Ruoss; A Weinacker; T A Raffin
Journal:  Chest       Date:  1999-11       Impact factor: 9.410

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Authors:  M Mock; A Fouet
Journal:  Annu Rev Microbiol       Date:  2001       Impact factor: 15.500

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Authors:  P C Hanna; D Acosta; R J Collier
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

8.  Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.

Authors:  S H Leppla
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

9.  Anthrax protective antigen forms oligomers during intoxication of mammalian cells.

Authors:  J C Milne; D Furlong; P C Hanna; J S Wall; R J Collier
Journal:  J Biol Chem       Date:  1994-08-12       Impact factor: 5.157

10.  Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice.

Authors:  Mahtab Moayeri; Diana Haines; Howard A Young; Stephen H Leppla
Journal:  J Clin Invest       Date:  2003-09       Impact factor: 14.808
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  7 in total

1.  Acquired coagulant factor VIII deficiency induced by Bacillus anthracis lethal toxin in mice.

Authors:  Der-Shan Sun; Po-Chien Lee; Jyh-Hwa Kau; Yung-Luen Shih; Hsin-Hsien Huang; Chen-Ru Li; Chin-Cheng Lee; Yu-Ping Wu; Kuo-Ching Chen; Hsin-Hou Chang
Journal:  Virulence       Date:  2015-04-23       Impact factor: 5.882

2.  Murine innate immune response to virulent toxigenic and nontoxigenic Bacillus anthracis strains.

Authors:  Melissa Drysdale; Gwyneth Olson; Theresa M Koehler; Mary F Lipscomb; C Rick Lyons
Journal:  Infect Immun       Date:  2007-01-22       Impact factor: 3.441

3.  Modeling the host response to inhalation anthrax.

Authors:  Judy Day; Avner Friedman; Larry S Schlesinger
Journal:  J Theor Biol       Date:  2011-02-03       Impact factor: 2.691

Review 4.  Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins.

Authors:  Holger Barth; Klaus Aktories; Michel R Popoff; Bradley G Stiles
Journal:  Microbiol Mol Biol Rev       Date:  2004-09       Impact factor: 11.056

5.  Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin.

Authors:  Wenxin Wu; Harshini Mehta; Kaushik Chakrabarty; J Leland Booth; Elizabeth S Duggan; Krupa B Patel; Jimmy D Ballard; K Mark Coggeshall; Jordan P Metcalf
Journal:  J Immunol       Date:  2009-10-07       Impact factor: 5.422

6.  The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax.

Authors:  Kenneth Mark Coggeshall; Florea Lupu; Jimmy Ballard; Jordan P Metcalf; Judith A James; Darise Farris; Shinichiro Kurosawa
Journal:  J Cell Mol Med       Date:  2013-06-07       Impact factor: 5.310

7.  Lessons for control of heroin-associated anthrax in Europe from 2009-2010 outbreak case studies, London, UK.

Authors:  Aula Abbara; Tim Brooks; Graham P Taylor; Marianne Nolan; Hugo Donaldson; Maribel Manikon; Alison Holmes
Journal:  Emerg Infect Dis       Date:  2014-07       Impact factor: 6.883
  7 in total

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