| Literature DB >> 12951120 |
Carol K Wada1, Robin R Frey, Zhiqin Ji, Michael L Curtin, Robert B Garland, James H Holms, Junling Li, Lori J Pease, Jun Guo, Keith B Glaser, Patrick A Marcotte, Paul L Richardson, Shannon S Murphy, Jennifer J Bouska, Paul Tapang, Terrance J Magoc, Daniel H Albert, Steven K Davidsen, Michael R Michaelides.
Abstract
Alpha-keto ester and amides were found to be potent inhibitors of histone deacetylase. Nanomolar inhibitors against the isolated enzyme and sub-micromolar inhibitors of cellular proliferation were obtained. The alpha-keto amide 30 also exhibited significant anti-tumor effects in an in vivo tumor model.Entities:
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Year: 2003 PMID： 12951120 DOI： 10.1016/s0960-894x(03)00685-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823