Literature DB >> 12951113

Synthesis of pyrimidinopyridine-triazene conjugates targeted to abl tyrosine kinase.

Zakaria Rachid1, Athanasia Katsoulas, Fouad Brahimi, Bertrand Jacques Jean-Claude.   

Abstract

The synthesis and abl tyrosine kinase inhibitory activities of alkyltriazenes conjugated to phenylaminopyrimidines are described. Significant abl inhibitory activities were observed only when a benzamido spacer was inserted between the 1,2,3-triazene chain and the 2-phenyaminopyridopyrimidine moiety.

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Year:  2003        PMID： 12951113     DOI： 10.1016/s0960-894x(03)00553-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  ZRF4, a combi-molecule with increased efficacy as compared with the individual components in chronic lymphocytic leukemia lymphocytes in vitro.

Authors:  L Amrein; Z Rachid; B Jean-Claude; D Soulières; R Aloyz; L Panasci
Journal:  Leukemia       Date:  2011-06-07       Impact factor: 11.528

2.  Assessment of the biological potential of diaryltriazene-derived triazene compounds.

Authors:  Patricia de Maria Silva Figueirêdo; José Costa Sampaio Filho; Alzirene de Jesus Sales Sodré; José Ribamar de Castro Júnior; Ingrid Santos Gonçalves; Rodrigo Vieira Blasques; Rodrigo S Correa; Benedicto Augusto Vieira Lima; Larissa Dos Anjos Marques; Denise Fernandes Coutinho; Ana Paula Silva de Azevedo Dos Santos; Tássio Rômulo Silva Araújo Luz; Rita de Cassia Mendonça de Miranda; Julliana Ribeiro Alves Dos Santos; Antonio Carlos Doriguetto; María Isabel Pividori; Manfredo Hörner; Paulo Cesar Mendes Villis
Journal:  Sci Rep       Date:  2021-01-28       Impact factor: 4.379

3.  Synthesis, and In-vitro Cytotoxicity Studies of a Series of Triazene Derivatives on Human Cancer Cell Lines.

Authors:  Hadi Adibi; Mohammad Bagher Majnooni; Ali Mostafaie; Kamran Mansouri; Moslem Mohammadi
Journal:  Iran J Pharm Res       Date:  2013       Impact factor: 1.696

4.  Design and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells.

Authors:  Sheng Chang; Shi-Liang Yin; Jian Wang; Yong-Kui Jing; Jin-Hua Dong
Journal:  Molecules       Date:  2009-10-19       Impact factor: 4.411
  4 in total

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