Literature DB >> 12951102

Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor.

Zhengming Chen1, Wendy S Miller, Shen Shan, Kenneth J Valenzano.   

Abstract

Based on literature structures, we proposed a pharmacophore for NOP receptor ligands and used it as a guide for the design of a focused piperidine library and an optimization library. Potent NOP receptor agonists and antagonists were obtained from these libraries as well as a few potent, mu selective agonists.

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Year:  2003        PMID： 12951102     DOI： 10.1016/s0960-894x(03)00665-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Small-molecule agonists and antagonists of the opioid receptor-like receptor (ORL1, NOP): ligand-based analysis of structural factors influencing intrinsic activity at NOP.

Authors:  Nurulain Zaveri; Faming Jiang; Cris Olsen; Willma Polgar; Lawrence Toll
Journal:  AAPS J       Date:  2005-10-05       Impact factor: 4.009

2.  Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.

Authors:  Dianqing Sun; Michael S Scherman; Victoria Jones; Julian G Hurdle; Lisa K Woolhiser; Susan E Knudson; Anne J Lenaerts; Richard A Slayden; Michael R McNeil; Richard E Lee
Journal:  Bioorg Med Chem       Date:  2009-04-09       Impact factor: 3.641

3.  Metal-free hydroarylation of the side chain carbon-carbon double bond of 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles in triflic acid.

Authors:  Anna S Zalivatskaya; Dmitry S Ryabukhin; Marina V Tarasenko; Alexander Yu Ivanov; Irina A Boyarskaya; Elena V Grinenko; Ludmila V Osetrova; Eugeniy R Kofanov; Aleksander V Vasilyev
Journal:  Beilstein J Org Chem       Date:  2017-05-11       Impact factor: 2.883

4.  A facile synthesis for novel loperamide analogs as potential μ opioid receptor agonists.

Authors:  Xiaofeng Bao; Duliang Liu; Yanyan Jin; Yao Yang
Journal:  Molecules       Date:  2012-12-03       Impact factor: 4.411
  4 in total

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