| Literature DB >> 12951096 |
Thanh Lam1, Taotao Ling, Chinmay Chowdhury, Ta-Hsiang Chao, F R Bahjat, G K Lloyd, Lyle L Moldawer, Michael A Palladino, Emmanuel A Theodorakis.
Abstract
The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-alpha synthesis and displayed good specificity in suppressing cytokine expression.Entities:
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Year: 2003 PMID： 12951096 DOI： 10.1016/s0960-894x(03)00669-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823